CHRNA3

Gene Name		cholinergic receptor, nicotinic, alpha 3 (neuronal)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Postsynaptic Density Integral Component Of Membrane Cell Junction Dendrite Neuronal Cell Body Postsynaptic Membrane
	Molecular Function	Acetylcholine-activated Cation-selective Channel Activity Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine Binding
	Biological Process	Ion Transport Regulation Of Smooth Muscle Contraction Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Synaptic Transmission Synaptic Transmission, Cholinergic Nervous System Development Locomotory Behavior Regulation Of Acetylcholine Secretion, Neurotransmission Ion Transmembrane Transport Behavioral Response To Nicotine Regulation Of Membrane Potential Regulation Of Dendrite Morphogenesis Regulation Of Excitatory Postsynaptic Membrane Potential Synaptic Transmission Involved In Micturition Cation Transmembrane Transport
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 22080838 19300482 20173748) Lung adenocarcinoma ( 19836008) Lung cancer ( 18385676 18385738 19654303 18780872) Nicotine dependence ( 18385739) Obesity-related traits ( 23251661) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Serum albumin level ( 23022100) Smoking behavior ( 20418889 20418890)
Protein-protein Interactions		2 interactors: CHRNB4 UBQLN1
Entrez ID		1136
HPRD ID		07511
Ensembl ID		ENSG00000080644
Uniprot IDs		P32297
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Involved In Micturition Micturition Behavioral Response To Nicotine Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Nicotine Excretion Regulation Of Cellular Response To Oxidative Stress Regulation Of Smooth Muscle Contraction Smooth Muscle Contraction Regulation Of Neurotransmitter Secretion Action Potential Renal System Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Response To Alkaloid Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Muscle Contraction Response To Endoplasmic Reticulum Stress Adult Behavior Regulation Of Protein Ubiquitination Regulation Of Signaling
Tagcloud ?		1x10 9x10 accounts adenocarcinoma b4 clptm1l conducting cyp1a1 dependence genetics gwa mediation nicotine nicotinic personalized rs1051730 rs12914385 rs2736100 rs2853676 rs31489 rs401681 smoking snps tert variations