OIP5 and VPS39

		OIP5	VPS39
Description		Opa interacting protein 5	VPS39 subunit of HOPS complex
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Chromocenter Cajal Body Nuclear Speck CENP-A Recruiting Complex	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Endosome Membrane Endomembrane System Membrane AP-3 Adaptor Complex HOPS Complex Late Endosome Membrane Lysosomal HOPS Complex
	Molecular Function	Protein Binding Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Chromosome Segregation Cell Communication CENP-A Containing Chromatin Assembly Cell Division Pericentric Heterochromatin Organization	Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Endocytic Recycling Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Autophagosome-lysosome Fusion Late Endosome To Lysosome Transport
Pathways		Deposition of new CENPA-containing nucleosomes at the centromere	SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Ulcerative colitis ( 28067908)
Interacting Genes		142 interacting genes: A1CF ABI2 ABI3 ABL2 AGXT BCAS2 BEX2 BFSP2 BLOC1S5 BRAF C1orf94 C21orf91 C7orf57 CASP10 CBY2 CCDC22 CCDC24 CCHCR1 CDR2L CEP57 CERK CHCHD2 CIMIP1 COX5B CRACR2A CTNNA3 DMRT3 DTNBP1 DTX2 DUSP21 EFHC1 EIF4ENIF1 ESS2 FAM161B FAM222B FOXJ1 FSD2 GADD45GIP1 GCC1 GEM GLIS2 GPANK1 GPS2 HAPLN2 HGS HJURP HOXB5 HOXB9 HOXC8 HSF4 IL16 KANK2 KDM1A KIF9 KLHL38 KLHL42 KNSTRN KRT14 KRT15 KRT27 KRT3 KRT35 KRT37 KRT40 KRT6B KRT75 KRT81 KRT83 KRT86 KRTAP13-2 KRTAP19-5 KRTAP19-6 LENG1 MECOM MED4 MEIS2 MGAT5B MIIP MIS18A MIS18BP1 MISP MORN3 MYEF2 MYRIP NDUFAB1 NECAB2 NUP54 NUP62 P4HA3 PATZ1 PEX19 PHETA1 PITX2 PLAGL2 POLR2J POU6F2 PRR35 PSMB1 RAB26 RABGEF1 RAF1 RARG RIBC1 RUNX1T1 RUSC1 S100Z SAMD7 SAXO1 SAXO4 SHISA6 SKIL SMARCE1 SNRNP25 SNRPB SOHLH1 SORBS3 SPATA24 SPMIP4 SYCE1L TEKT3 TEX12 TFAP2D TFIP11 TIMM8A TLX3 TMPO TPM3 TPRX1 TRIB3 TRIM73 TRIP6 TROAP TSSK3 USHBP1 USP2 USP54 WASHC1 YTHDF1 ZIC1 ZMAT1 ZNF417 ZNF655	7 interacting genes: HOOK1 MECOM RILP RUNX1 SNW1 STAT3 TFIP11
Entrez ID		11339	23339
HPRD ID		09352	10300
Ensembl ID		ENSG00000104147	ENSG00000166887
Uniprot IDs		O43482	Q96JC1
PDB IDs		7SFY	6ZE9
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Keratin Filament Protein Binding Supramolecular Fiber Organization Cytoskeleton Axonemal A Tubule Inner Sheath Cytoskeleton Organization Structural Molecule Activity Organelle Organization Sperm Flagellum Keratinization Motile Cilium CENP-A Containing Chromatin Assembly Pericentric Heterochromatin Organization CENP-A Recruiting Complex	Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Extracellular Matrix Organization Hematopoietic Stem Cell Proliferation Nuclear Speck Early Endosome To Late Endosome Transport Dynein Light Intermediate Chain Binding Negative Regulation Of DNA-templated Transcription Protein Homodimerization Activity Negative Regulation Of RNA Biosynthetic Process Endosome To Lysosome Transport Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Biosynthetic Process Core-binding Factor Complex Negative Regulation Of Transcription By RNA Polymerase II Stem Cell Proliferation Positive Regulation Of Myeloid Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Pericentric Heterochromatin Organization CENP-A Recruiting Complex Catalytic Step 2 Spliceosome Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Endosome Organization Intralumenal Vesicle Formation Cardiac Muscle Tissue Regeneration Nucleoplasm RNA Sequestering Activity Maintenance Of Cell Number Stem Cell Population Maintenance Lysosomal Transport Positive Regulation Of Vasculature Development Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Angiogenesis Regulation Of Macromolecule Metabolic Process Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation DNA-binding Transcription Factor Binding DNA Binding Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Regulation Of Metabolic Process Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3K9me2 Methyltransferase Activity
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