CD300A and VMA12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD300A	VMA12
Description		CD300a molecule	vacuolar ATPase assembly factor VMA12
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Vacuolar Proton-transporting V-type ATPase Complex COPI-coated Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Protein Binding Phosphatidylethanolamine Binding Signaling Receptor Activity	Protein Binding Oxysterol Binding
	Biological Process	Immune System Process Cell Adhesion Signal Transduction Negative Regulation Of B Cell Proliferation Negative Regulation Of Mast Cell Activation Involved In Immune Response Negative Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Mast Cell Degranulation Negative Regulation Of MAP Kinase Activity Regulation Of Innate Immune Response Negative Regulation Of Fibroblast Proliferation Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of NK T Cell Activation Negative Regulation Of Phagocytosis, Engulfment Negative Regulation Of Neutrophil Activation Negative Regulation Of Eosinophil Activation Negative Regulation Of Eosinophil Migration	Intracellular Iron Ion Homeostasis Lysosomal Lumen Acidification Cellular Response To Increased Oxygen Levels Vacuolar Proton-transporting V-type ATPase Complex Assembly Lysosomal Protein Catabolic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		6 interacting genes: KRT38 KRTAP10-3 SEC22A TMEM218 TMEM60 VMA12	17 interacting genes: AQP6 BIK CCR2 CD300A EBP ELOVL4 ERLIN1 IFNGR2 JAGN1 KASH5 LMNA REEP4 SLC10A4 STX1A STX4 TIMMDC1 TMEM14B
Entrez ID		11314	147007
HPRD ID		09492	12679
Ensembl ID		ENSG00000167851	ENSG00000244045
Uniprot IDs		J3QKQ4 Q9UGN4	Q8N511
PDB IDs		2Q87
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Microvillus Organization Negative Regulation Of Sodium Ion Transport Gamma-aminobutyric Acid Transport Endomembrane System Golgi Localization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Maintenance Of Cell Polarity Type 2 Metabotropic Glutamate Receptor Binding Glutathione Transport Plasma Membrane Protein Complex Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Microvillus Assembly Type 3 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Establishment Of Golgi Localization Negative Regulation Of Fibroblast Migration Channel Activator Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Gamma-aminobutyric Acid Transmembrane Transporter Activity Dopamine Receptor Binding Beta-2 Adrenergic Receptor Binding Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Phosphate Ion Absorption Chloride Channel Regulator Activity Intracellular Phosphate Ion Homeostasis Gamma-aminobutyric Acid Import Stereocilium Tip Growth Factor Receptor Binding Cerebrospinal Fluid Circulation Vacuolar Proton-transporting V-type ATPase Complex Assembly Lysosomal Protein Catabolic Process Proton-transporting V-type ATPase Complex Assembly Oxysterol Binding Vacuolar Proton-transporting V-type ATPase Complex Cellular Response To Increased Oxygen Levels Oligopeptide Transport Establishment Of Epithelial Cell Apical/basal Polarity Auditory Receptor Cell Stereocilium Organization COPI-coated Vesicle Membrane Protein Catabolic Process In The Vacuole Morphogenesis Of An Epithelium	Membrane Regulation Of Regulated Secretory Pathway Regulation Of Exocytosis Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway SNARE Complex Assembly Regulation Of Secretion By Cell Nuclear Envelope Organization Regulation Of Secretion Endoplasmic Reticulum Membrane Positive Regulation Of Synaptic Transmission Nitrate Transmembrane Transporter Activity Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrial Membrane Organelle Localization SNARE Complex Regulation Of Insulin Secretion Insulin Secretion Positive Regulation Of Regulated Secretory Pathway Regulation Of Peptide Hormone Secretion SNAP Receptor Activity Myosin Head/neck Binding Exocytosis Sphingomyelin Phosphodiesterase Activator Activity Cholesterol-5,6-oxide Hydrolase Activity Negative Regulation Of Secretion Negative Regulation Of Secretion By Cell Negative Regulation Of Eosinophil Activation Negative Regulation Of Exocytosis Negative Regulation Of Phagocytosis, Engulfment Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Nuclear Envelope PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Type II Interferon Receptor Activity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina SNARE Binding Vesicle Docking Regulation Of Vesicle-mediated Transport Positive Regulation Of Eosinophil Degranulation Membrane Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Storage Vacuole C-8 Sterol Isomerase Activity Cholestenol Delta-isomerase Activity
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