RDH13 and CYP3A5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RDH13	CYP3A5
Description		retinol dehydrogenase 13	cytochrome P450 family 3 subfamily A member 5
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Oxidoreductase Activity All-trans-retinol Dehydrogenase (NADP+) Activity	Monooxygenase Activity Iron Ion Binding Protein Binding Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Metal Ion Binding Testosterone 6-beta-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity
	Biological Process	Lipid Metabolic Process Response To High Light Intensity Retina Layer Formation Eye Photoreceptor Cell Development Retinol Metabolic Process Retinal Metabolic Process	Lipid Hydroxylation Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Alkaloid Catabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Aflatoxin Metabolic Process Oxidative Demethylation
Pathways		RA biosynthesis pathway	Xenobiotics Aflatoxin activation and detoxification
Drugs		Vitamin A	Cannabidiol Diacerein Nabiximols
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet distribution width ( 32888494)	Platelet count ( 29403010) Serum metabolite levels ( 23093944 33031748) Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		4 interacting genes: CFTR CYP3A5 GADD45G PSKH1	3 interacting genes: ATOH8 ETV5 RDH13
Entrez ID		112724	1577
HPRD ID		17963	05617
Ensembl ID		ENSG00000160439	ENSG00000106258
Uniprot IDs		B3KVA3 Q8NBN7	B7Z3P6 P20815
PDB IDs			5VEU
Enriched GO Terms of Interacting Partners?		Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Endoplasmic Reticulum Membrane Positive Regulation Of Tooth Mineralization Alcohol Metabolic Process Chloride Channel Inhibitor Activity Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Steroid Metabolic Process Chloride Channel Regulator Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Membrane Hyperpolarization Lipid Hydroxylation Testosterone 6-beta-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Oxidative Demethylation Alkaloid Catabolic Process Aflatoxin Metabolic Process Estrogen 2-hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Amelogenesis Alkaloid Metabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Endoplasmic Reticulum Demethylation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Toxin Metabolic Process Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Regulation Of Hormone Levels Water Transport Bicarbonate Transport Retinoic Acid Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Xenobiotic Catabolic Process Positive Regulation Of P38MAPK Cascade Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process	Male Germ-line Stem Cell Asymmetric Division Response To High Light Intensity Germ-line Stem Cell Division Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Asymmetric Cell Division Myoblast Proliferation Positive Regulation Of Endothelial Cell Differentiation Response To Light Intensity All-trans-retinol Dehydrogenase (NADP+) Activity Sequence-specific Double-stranded DNA Binding Retinal Metabolic Process
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