SUPT16H and NGDN

		SUPT16H	NGDN
Description		SPT16 homolog, facilitates chromatin remodeling subunit	neuroguidin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Transcription Elongation Factor Complex FACT Complex	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Filopodium Axon Dendrite Small-subunit Processome Cell Projection
	Molecular Function	RNA Binding Protein Binding Nucleosome Binding	RNA Binding Protein Binding
	Biological Process	DNA Replication DNA Repair Nucleosome Assembly Nucleosome Disassembly Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II DNA Damage Response Positive Regulation Of DNA-templated Transcription, Elongation	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Regulation Of Translation Ribosomal Small Subunit Biogenesis
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		15 interacting genes: CCT6A GTF2E2 H2AC13 H3-3A H3C1 H4C1 MCM3 MCM4 NEK9 PARP1 RNF10 SREK1 SRPK2 SUMO2 USP7	4 interacting genes: CSNK2B MFAP1 NOM1 SRPK2
Entrez ID		11198	25983
HPRD ID		16088	10708
Ensembl ID		ENSG00000092201	ENSG00000129460
Uniprot IDs		Q9Y5B9	Q8NEJ9
PDB IDs		4Z2M 4Z2N 5E5B 5UMT 5UMU 5XM2 6UPK 6UPL 8I17 8YJF 8YJM 9EH2	7MQ8
Enriched GO Terms of Interacting Partners?		Chromosome Chromosome, Telomeric Region Chromatin Remodeling Structural Constituent Of Chromatin Chromatin Organization Telomere Organization Nucleus Nucleosome Mitotic DNA Replication Initiation Regulation Of Establishment Of Protein Localization To Telomere Nucleoplasm Regulation Of Establishment Of Protein Localization To Chromosome RNA Binding DNA Binding CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization DNA Strand Elongation Involved In DNA Replication Regulation Of DNA-templated DNA Replication Initiation Epigenetic Regulation Of Gene Expression Regulation Of Telomere Maintenance Nucleosome Assembly Single-stranded DNA Helicase Activity DNA Strand Elongation Nucleic Acid Metabolic Process Chromosome Organization Protein Heterodimerization Activity Nucleosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Replication Initiation Regulation Of Macromolecule Metabolic Process Protein-containing Complex Negative Regulation Of Gene Expression, Epigenetic Protein-DNA Complex Assembly NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Macromolecule Metabolic Process NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Protein Localization To Chromatin DNA Repair Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process DNA Recombination	Detection Of Chemical Stimulus Involved In Sensory Perception Of Smell Olfactory Receptor Activity Sensory Perception Of Smell Detection Of Chemical Stimulus Involved In Sensory Perception Detection Of Chemical Stimulus Sensory Perception Of Chemical Stimulus Detection Of Stimulus Involved In Sensory Perception Detection Of Stimulus Negative Regulation Of Viral Process G Protein-coupled Receptor Activity Regulation Of Viral Life Cycle Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Sensory Perception Nuclear Speck Organization FACT Complex Regulation Of Viral Process Release From Viral Latency Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Hair Follicle Maturation
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