PWP1 and DCAF1

Number of citations of the paper that reports this interaction (PubMedID 33355139)
50

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		PWP1	DCAF1
Description		PWP1 homolog, endonuclein	DDB1 and CUL4 associated factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Nucleolus Golgi Apparatus	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Histone Chaperone Activity Histone H4K20me3 Reader Activity	Nucleotide Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Nuclear Estrogen Receptor Binding Protein Serine Kinase Activity Histone H2AT120 Kinase Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Chromatin Organization DNA-templated Transcription Regulation Of DNA-templated Transcription RRNA Processing Ribosome Biogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Base-excision Repair, AP Site Formation Via Deaminated Base Removal
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181)	Asthma ( 32296059)
Interacting Genes		9 interacting genes: APP CUL4B DAPK1 DCAF1 HOXA3 NFYA OGT SMURF1 USP7	25 interacting genes: ATM ATR CCP110 CD274 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF IRF1 KATNA1 LATS1 LATS2 NF2 PLK4 PRKDC PWP1 PYGO2 RAG1 TET2 TP53 UBE2D2 UBE2D3 USP2
Entrez ID		11137	9730
HPRD ID		11464	11674
Ensembl ID		ENSG00000136045	ENSG00000145041
Uniprot IDs		B4DJV5 Q13610	Q9Y4B6
PDB IDs			3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45 6ZUE 6ZX9 7OKQ 7SSE 7UFV 7V7B 7V7C 8F8E 8OG5 8OG6 8OG7 8OG8 8OG9 8OGA 8OGB 8OGC 8OO5 8OOD 9B9H 9B9T 9B9W 9BA2 9BHR 9BHS 9C1Q 9D4E 9DLW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Cul4-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Protein Metabolic Process Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Metabolic Process DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Rhythmic Process Regulation Of Gluconeogenesis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Engulfment Of Target By Autophagosome Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of ATP Metabolic Process Chromatin Organization Post-translational Protein Modification Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Purine Nucleotide Metabolic Process TOR Signaling Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Protein Localization To Vacuole	Histone H2AXS139 Kinase Activity Nucleus Chromatin Organization Regulation Of Cell Cycle Positive Regulation Of Cellular Component Biogenesis DNA Binding DNA Repair Somatic Cell DNA Recombination Chromosome Organization Nucleoplasm DNA Metabolic Process DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Telomere Organization Response To Gamma Radiation Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Signal Transduction In Response To DNA Damage V(D)J Recombination Chromatin Remodeling Centrosome DNA-dependent Protein Kinase Activity Chromosome, Telomeric Region Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Cellular Response To Gamma Radiation Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Protein-containing Complex Assembly Pre-B Cell Allelic Exclusion DNA Damage Response DNA Damage Checkpoint Signaling Macromolecule Metabolic Process ATP Binding Nucleotide Binding Protein Serine/threonine Kinase Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Metabolic Process Regulation Of T Cell Apoptotic Process Regulation Of Signal Transduction By P53 Class Mediator Replication Fork Processing B Cell Lineage Commitment Regulation Of Protein-containing Complex Assembly Regulation Of Organelle Assembly Regulation Of Telomere Maintenance Via Telomerase T Cell Differentiation In Thymus Response To Radiation Regulation Of Hippo Signaling Somitogenesis
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