OS9 and FAIM2

		OS9	FAIM2
Description		OS9 endoplasmic reticulum lectin	Fas apoptotic inhibitory molecule 2
Image			No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Membrane Raft Synapse Postsynaptic Membrane
	Molecular Function	Protease Binding Protein Binding Carbohydrate Binding Glycosylation-dependent Protein Binding	Calcium Channel Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Intracellular Protein Localization Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Response To Ischemia Apoptotic Process Cerebellum Development Cerebellar Purkinje Cell Layer Development Cerebellar Granular Layer Development Cerebellar Purkinje Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Neuron Apoptotic Process Calcium Ion Transmembrane Transport Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Apoptotic Signaling Pathway
Pathways		ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)	Adult body size ( 32376654) Alcohol consumption (drinks per week) ( 30643258) Blood urea nitrogen levels ( 31152163) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat mass ( 28552196) Body mass index ( 19079260 28892062 28552196 28448500 20935630) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Breast size ( 27182965) Childhood body mass index ( 26604143) Hip circumference ( 25673412 28552196) Menarche (age at onset) ( 27182965) Obese vs. thin ( 30677029) Obesity (extreme) ( 30677029) Obsessive-compulsive disorder ( 22889921) Trunk fat mass ( 28552196) Type 2 diabetes ( 32499647) Urate levels ( 31578528) Waist circumference ( 28552196 19557197) Weight ( 28552196 19079260)
Interacting Genes		19 interacting genes: ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FOXM1 HIF1A LINC00839 MEP1B RBX1 SMAD2 SNRPD2 SREBF2 TRPV4 USP40 ZNF512B	5 interacting genes: EPN2 FAS GGT6 SLC22A2 STK11
Entrez ID		10956	23017
HPRD ID		17804	09184
Ensembl ID		ENSG00000135506	ENSG00000135472
Uniprot IDs		A0A8V8TPZ4 A0A8V8TQI8 A0A8V8TR34 Q13438	Q9BWQ8
PDB IDs		3AIH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ossification L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity Regulation Of Ossification Regulation Of Generation Of Precursor Metabolites And Energy Intracellular Oxygen Homeostasis Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Nodal Signaling Pathway I-SMAD Binding Regulation Of MiRNA Transcription Peptide Hormone Secretion Regulation Of Macroautophagy Peptide Secretion Dioxygenase Activity Protein Hydroxylation Regulation Of Myeloid Cell Differentiation Regulation Of MiRNA Metabolic Process Negative Regulation Of Bone Mineralization 2-oxoglutarate-dependent Dioxygenase Activity Hormone Secretion Cellular Response To Stress Positive Regulation Of Transcription By RNA Polymerase II Hormone Transport Peptide Transport Ferrous Iron Binding Positive Regulation Of Myeloid Cell Differentiation Regulation Of Neuron Apoptotic Process Iron Ion Binding Negative Regulation Of MiRNA Transcription Positive Regulation Of Erythrocyte Differentiation Activin Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Hypoxia Response To Decreased Oxygen Levels Regulation Of Apoptotic Process Response To Hypoxia Negative Regulation Of Biomineral Tissue Development Assembly Of Large Subunit Precursor Of Preribosome D-gluconate Metabolic Process Phosphogluconate Dehydrogenase (decarboxylating) Activity Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Monoatomic Cation Channel Activity Positive Regulation Of Protein-containing Complex Disassembly Lytic Vacuole Monocyte Activation Involved In Immune Response Positive Regulation Of Deacetylase Activity Osmosensor Activity	Transmembrane Signaling Receptor Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Necroptotic Signaling Pathway Death-inducing Signaling Complex Activation-induced Cell Death Of T Cells Tumor Necrosis Factor Receptor Activity CD95 Death-inducing Signaling Complex Positive Regulation Of Signaling Cellular Response To Hyperoxia Fas Signaling Pathway Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Microtubule-based Process RNA Polymerase I Core Binding Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Developmental Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Regulation Of Cellular Localization Regulation Of Anatomical Structure Morphogenesis Basal Plasma Membrane Positive Regulation Of Phosphorylation Regulation Of Immature T Cell Proliferation In Thymus ERBB2-ERBB3 Signaling Pathway Regulation Of Kinase Activity ERBB3 Signaling Pathway Immature T Cell Proliferation In Thymus ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Regulation Of Protein Localization ERBB4 Signaling Pathway Positive Regulation Of Protein Phosphorylation Basolateral Plasma Membrane Serotonin Uptake Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Azole Transmembrane Transport Choline Transport Norepinephrine Uptake Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Across Blood-brain Barrier Spermidine Transport Efflux Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity
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