TXNL4A and ALG13

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		TXNL4A	ALG13
Description		thioredoxin like 4A	ALG13 UDP-N-acetylglucosaminyltransferase subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane UDP-N-acetylglucosamine Transferase Complex Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Catalytic Activity N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Hydrolase Activity
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cell Division	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Proteolysis
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG14 causes ALG14-CMS
Drugs
Diseases
GWAS			Rosacea symptom severity ( 29771307) Shoulder impingement or rotator cuff tear ( 33482370)
Interacting Genes		20 interacting genes: ALG13 ANKHD1 CD2BP2 CPSF7 DDIT4L DMRTB1 ERBB3 EXOC5 HNRNPF KRT31 LARP4 LZTS2 PQBP1 PRRC2B QKI RBM22 RBPMS RHEBL1 SNW1 TNRC6A	30 interacting genes: ATN1 ATXN1L BAG4 CPSF7 DMRTB1 EIF4ENIF1 ESRP1 EXOSC7 GRN HOXA1 KRT31 MAPKBP1 NXF2 PCM1 PITX1 PRRC2B QKI RBFOX1 RBFOX2 RBPMS RERE RHOU ROR2 RPL14 SF1 TRIM14 TXNL4A U2AF1 YTHDF3 ZC3H10
Entrez ID		10907	79868
HPRD ID		18252	06542
Ensembl ID		ENSG00000141759	ENSG00000101901
Uniprot IDs		K7ESL1 P83876	A0A087WT15 A0A087WX43 Q9NP73
PDB IDs		1PQN 1QGV 1SYX 3JCR 4BWQ 4BWS 4CDO 5O9Z 6AH0 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Nucleic Acid Binding MRNA Processing MRNA Splicing, Via Spliceosome RNA Binding RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Splicing Cytoplasmic Stress Granule Catalytic Step 2 Spliceosome Pre-mRNA Binding Transcription Coactivator Activity Regulation Of MRNA Splicing, Via Spliceosome MRNA 3'-UTR Binding Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing U2-type Catalytic Step 2 Spliceosome Positive Regulation Of MRNA Metabolic Process RNA Metabolic Process Ribonucleoprotein Complex Binding Spliceosomal Complex Internal N(7)-methylguanine-containing RNA Reader Activity Positive Regulation Of RNA Splicing N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Primary Ureteric Bud Growth	RNA Binding MRNA Binding RNA Processing Nucleic Acid Binding MRNA Processing MRNA Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process RNA Splicing RNA Metabolic Process Cytoplasmic Stress Granule U2AF Complex Regulation Of MRNA Splicing, Via Spliceosome Nucleus Negative Regulation Of Metabolic Process Regulation Of MRNA Processing Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Defense Response To Bacterium MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Transcription Corepressor Activity Negative Regulation Of RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of Nucleobase-containing Compound Metabolic Process P-body Protein Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MRNA Catabolic Process Stress Granule Assembly Positive Regulation Of Aspartic-type Peptidase Activity Semicircular Canal Formation Internal N(7)-methylguanine-containing RNA Reader Activity Negative Regulation Of MRNA Modification Regulation Of Inner Ear Auditory Receptor Cell Fate Specification Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MiRNA Binding Positive Regulation Of MRNA Metabolic Process RNA Transport Nucleobase-containing Compound Metabolic Process
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