TRAFD1 and NGLY1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TRAFD1	NGLY1
Gene Name		TRAF-type zinc finger domain containing 1	N-glycanase 1
Image
Gene Ontology Annotations	Cellular Component		Cytoplasm
	Molecular Function	Protein Binding Metal Ion Binding	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding
	Biological Process	Response To Cytokine Negative Regulation Of Innate Immune Response	Glycoprotein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Hemoglobin ( 19862010) Type 1 diabetes ( 17554300)
Protein-Protein Interactions		4 interactors: HTT NGLY1 TRAF6 UBC	12 interactors: APP FAF1 GUCD1 NSFL1C RAD23A RAD23B SRPK2 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP
Entrez ID		10906	55768
HPRD ID		10994	10118
Ensembl ID		ENSG00000135148	ENSG00000151092
Uniprot IDs		O14545	Q96IV0
PDB IDs		2D9K	2CCQ 2CM0
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway JNK Cascade Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Neural Plate Formation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Antigen Receptor-mediated Signaling Pathway Activation Of MAPK Activity Activation Of Innate Immune Response Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Protein Polyubiquitination Circadian Rhythm Morphogenesis Of Embryonic Epithelium Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Death Death Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Regulation Of Protein Ubiquitination Endosomal Transport Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Phosphatase Type 2A Activity Neurotrophin TRK Receptor Signaling Pathway	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Nuclear Envelope Reassembly Regulation Of Protein Catabolic Process Nucleus Organization Response To Stress Cellular Response To Stress Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Proteolysis Autophagic Vacuole Assembly Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stimulus Macroautophagy Nuclear Envelope Organization Regulation Of Viral Genome Replication Nuclear Speck Organization Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Viral Process Golgi Organization Protein Metabolic Process Nucleotide-excision Repair Regulation Of Metabolic Process Synaptic Growth At Neuromuscular Junction Nucleotide-excision Repair, DNA Damage Recognition Cellular Component Assembly Vacuole Organization Collateral Sprouting In Absence Of Injury Membrane Fusion Cellular Response To Starvation Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Collateral Sprouting Axon Midline Choice Point Recognition Retrograde Protein Transport, ER To Cytosol
Tagcloud ?			ablation acetylglucosaminidase catalyzed consequences cytosolic deglycosylating deglycosylation dysregulation emerging endo engase erad fibroblast generating glcnac glycanase glycoprotein herein knockout mammals mef misfolded phenotypic pngase precise prone restored unconventional underscores
Tagcloud (Difference) ?			ablation acetylglucosaminidase catalyzed consequences cytosolic deglycosylating deglycosylation dysregulation emerging endo engase erad fibroblast generating glcnac glycanase glycoprotein herein knockout mammals mef misfolded phenotypic pngase precise prone restored unconventional underscores
Tagcloud (Intersection) ?