TRAFD1 and NGLY1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		TRAFD1	NGLY1
Description		TRAF-type zinc finger domain containing 1	N-glycanase 1
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GO Annotations	Cellular Component	Mitochondrion	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Innate Immune Response	Protein Folding Glycoprotein Catabolic Process Positive Regulation Of BMP Signaling Pathway
Pathways			N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 30718733) Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Body mass index ( 25673413 26426971) Coffee consumption ( 29367735) Confectionary intake ( 33632354) Hemoglobin ( 19862010) Hemoglobin levels ( 32327693) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Response to alcohol consumption (flushing response) ( 29460428) Spleen volume ( 34128465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 17554300) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: CFTR HTT NGLY1 TRAF6 UBC	19 interacting genes: APP BICRAL FAF1 GUCD1 NPAS2 NSFL1C PAX5 PAX6 RAD23A RAD23B SRPK2 TCF12 TRAFD1 TRIM54 UBC UBQLN1 UBXN2B VCP VMAC
Entrez ID		10906	55768
HPRD ID		10994	10118
Ensembl ID		ENSG00000135148	ENSG00000151092
Uniprot IDs		O14545	Q96IV0
PDB IDs		2D9K	2CCQ 2CM0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Odontogenesis Of Dentin-containing Tooth Endosome Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Establishment Of Spindle Localization Establishment Of Mitotic Spindle Localization Spindle Localization Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity	Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Modification-dependent Protein Catabolic Process Proteasome Complex VCP-NSFL1C Complex Negative Regulation Of Protein Localization To Centrosome Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Mitotic Spindle Orientation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Microtubule Cytoskeleton Organization Involved In Mitosis Proteolysis Regulation Of Mitotic Centrosome Separation VCP-NPL4-UFD1 AAA ATPase Complex Establishment Of Spindle Localization Spindle Localization Macromolecule Catabolic Process Positive Regulation Of Cell Cycle HMG Box Domain Binding Regulation Of Protein Localization To Centrosome Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization Proteasome Binding Ubiquitin-specific Protease Binding ERAD Pathway Autophagosome Assembly Autophagosome Organization Negative Regulation Of Hippo Signaling Nuclear Membrane Reassembly Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Viral Genome Replication Response To Stress Microtubule-based Process Ubiquitin Protein Ligase Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Catabolic Process Central Nervous System Development Regulation Of Response To Calcium Ion
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