TRAFD1

Description		TRAF-type zinc finger domain containing 1
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GO Annotations	Cellular Component	Mitochondrion
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Innate Immune Response
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 30718733) Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Body mass index ( 25673413 26426971) Coffee consumption ( 29367735) Confectionary intake ( 33632354) Hemoglobin ( 19862010) Hemoglobin levels ( 32327693) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Response to alcohol consumption (flushing response) ( 29460428) Spleen volume ( 34128465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 17554300) White blood cell count ( 32888494)
Novel Interacting Genes		4 novel interacting genes: ESPL1 KCNMB4 PRPF40B PTPRD
Interacting Genes		5 interacting genes: CFTR HTT NGLY1 TRAF6 UBC
Entrez ID		10906
HPRD ID		10994
Ensembl ID		ENSG00000135148
Uniprot IDs		O14545
PDB IDs		2D9K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Odontogenesis Of Dentin-containing Tooth Endosome Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Establishment Of Spindle Localization Establishment Of Mitotic Spindle Localization Spindle Localization Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity
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