TRAFD1 and PRPF40B

		TRAFD1	PRPF40B
Description		TRAF-type zinc finger domain containing 1	pre-mRNA processing factor 40B
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Nucleus U1 SnRNP Nuclear Matrix Nuclear Speck U2-type Prespliceosome
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Innate Immune Response	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 30718733) Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Body mass index ( 25673413 26426971) Coffee consumption ( 29367735) Confectionary intake ( 33632354) Hemoglobin ( 19862010) Hemoglobin levels ( 32327693) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Response to alcohol consumption (flushing response) ( 29460428) Spleen volume ( 34128465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 17554300) White blood cell count ( 32888494)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
Interacting Genes		5 interacting genes: CFTR HTT NGLY1 TRAF6 UBC	5 interacting genes: FUBP1 HLA-DRA HTT MECP2 RNF10
Entrez ID		10906	25766
HPRD ID		10994	11044
Ensembl ID		ENSG00000135148	ENSG00000110844
Uniprot IDs		O14545	A0A8Z5ADK7 F8VU11 Q6NWY9
PDB IDs		2D9K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Odontogenesis Of Dentin-containing Tooth Endosome Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Establishment Of Spindle Localization Establishment Of Mitotic Spindle Localization Spindle Localization Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity	Cognition Regulation Of Glial Cell Proliferation
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