EZH1

Name	enhancer of zeste 1 polycomb repressive complex 2 subunit
Structure
Interactors	3 interactors: E2F6 EED ZMYND11
GO Annotations	Cellular Component	Chromosome, Telomeric Region Heterochromatin Nucleus Nucleoplasm ESC/E(Z) Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Nucleosome Binding Histone Methyltransferase Activity Histone Binding Histone H3K27 Methyltransferase Activity Molecular Condensate Scaffold Activity Histone H3K27 Trimethyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Anatomical Structure Morphogenesis Hippocampus Development Heterochromatin Formation Subtelomeric Heterochromatin Formation Methylation Positive Regulation Of Transcription By RNA Polymerase II
Drugs	Tazemetostat
GWAS	A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Height ( 31562340 ) Waist-hip index ( 34021172 )
Entrez ID	2145
HPRD ID	03397
Ensembl ID	ENSG00000108799
Uniprot IDs	A0A0A0MSY9 Q92800
PDB IDs	7KSO 7KSR 7KTP 7TD5
GO Terms Enriched among Interactors ?	Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Adaxial/abaxial Pattern Formation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Pronucleus Sex Chromatin Histone H3K36me3 Reader Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process ESC/E(Z) Complex Facultative Heterochromatin Formation Chromatin Silencing Complex Negative Regulation Of Macromolecule Metabolic Process Genomic Imprinting Regulation Of DNA-templated Transcription MLL1 Complex Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Epigenetic Programming Of Gene Expression Chromosome Nucleosome Binding Spinal Cord Development Negative Regulation Of JNK Cascade Chromatin Organization Regulation Of RNA Metabolic Process Oligodendrocyte Differentiation Transcription Corepressor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm