EZH1 and E2F6

Number of citations of the paper that reports this interaction (PMID 16565076)
5

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EZH1	E2F6
Gene Name		enhancer of zeste 1 polycomb repressive complex 2 subunit	E2F transcription factor 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm ESC/E(Z) Complex	Nucleus Transcription Factor Complex MLL1 Complex
	Molecular Function	Chromatin Binding Histone Methyltransferase Activity (H3-K27 Specific)	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Anatomical Structure Morphogenesis Histone H3-K27 Methylation	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS			Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		3 interactors: E2F6 EED ZMYND11	14 interactors: APP ARAF BMI1 E2F1 EPC1 EZH1 EZH2 KRTAP10-7 PCGF6 RING1 RYBP TFDP1 TFDP2 ZMYND11
Entrez ID		2145	1876
HPRD ID		03397	04251
Ensembl ID		ENSG00000108799	ENSG00000169016
Uniprot IDs		Q92800	G5E936 O75461 Q53YM3 Q6Q9Z5 Q6Q9Z6
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Histone H3-K27 Methylation Regulation Of Histone H3-K27 Methylation Chromatin Modification RNA Metabolic Process Chromatin Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Gene Expression By Genetic Imprinting Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of JNK Cascade Genetic Imprinting Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Histone Methylation Chromosome Organization Regulation Of Transcription, DNA-templated Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription, Elongation Regulation Of Histone Methylation Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Histone Modification Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Cell Cycle Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Histone Methylation Regulation Of Histone Modification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of MAPK Cascade G1/S Transition Of Mitotic Cell Cycle Regulation Of JNK Cascade	Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromatin Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone Modification Nucleobase-containing Compound Metabolic Process Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Chromosome Organization Histone Ubiquitination Notch Signaling Pathway Biosynthetic Process Anoikis Peptidyl-lysine Modification Histone H3-K27 Methylation Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Histone H2A Monoubiquitination Histone H2A Ubiquitination Histone Monoubiquitination Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic
Tagcloud ?		coimmunoprecipitation combs continuously delimited demonstrates directed discuss disrupt drosophila earlier embryo embryogenesis enhancer esc evolution extra heed homologs hybrid impair maintain partnership pc polycomb repressors silencing zeste	193a accumulating alters attenuate bimodal cd117 cd44 chemoresistance competition complexity conjecture constitute dataset experimentally initiating kit mathematical microrna namely ocic ovarian persistence picture polycomb predicts switching tcga unravel ways
Tagcloud (Difference) ?		coimmunoprecipitation combs continuously delimited demonstrates directed discuss disrupt drosophila earlier embryo embryogenesis enhancer esc evolution extra heed homologs hybrid impair maintain partnership pc repressors silencing zeste	193a accumulating alters attenuate bimodal cd117 cd44 chemoresistance competition complexity conjecture constitute dataset experimentally initiating kit mathematical microrna namely ocic ovarian persistence picture predicts switching tcga unravel ways
Tagcloud (Intersection) ?		polycomb