EZH1 and E2F6

Number of citations of the paper that reports this interaction (PubMedID 16565076)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EZH1	E2F6
Description		enhancer of zeste 1 polycomb repressive complex 2 subunit	E2F transcription factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Heterochromatin Nucleus Nucleoplasm ESC/E(Z) Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex MLL1 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Nucleosome Binding Histone Methyltransferase Activity Histone Binding Histone H3K27 Methyltransferase Activity Molecular Condensate Scaffold Activity Histone H3K27 Trimethyltransferase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Anatomical Structure Morphogenesis Hippocampus Development Heterochromatin Formation Subtelomeric Heterochromatin Formation Methylation Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways			G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs		Tazemetostat
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Height ( 31562340) Waist-hip index ( 34021172)	Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Sudden cardiac arrest ( 21658281)
Interacting Genes		3 interacting genes: E2F6 EED ZMYND11	27 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11
Entrez ID		2145	1876
HPRD ID		03397	04251
Ensembl ID		ENSG00000108799	ENSG00000169016
Uniprot IDs		A0A0A0MSY9 Q92800	A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5
PDB IDs		7KSO 7KSR 7KTP 7TD5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Adaxial/abaxial Pattern Formation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Pronucleus Sex Chromatin Histone H3K36me3 Reader Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process ESC/E(Z) Complex Facultative Heterochromatin Formation Chromatin Silencing Complex Negative Regulation Of Macromolecule Metabolic Process Genomic Imprinting Regulation Of DNA-templated Transcription MLL1 Complex Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Epigenetic Programming Of Gene Expression Chromosome Nucleosome Binding Spinal Cord Development Negative Regulation Of JNK Cascade Chromatin Organization Regulation Of RNA Metabolic Process Oligodendrocyte Differentiation Transcription Corepressor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm	Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Constitutive Heterochromatin Formation Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Heterochromatin Formation PcG Protein Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Heterochromatin ESC/E(Z) Complex Positive Regulation Of Transcription By RNA Polymerase II PRC1 Complex Regulation Of Cell Cycle Histone H3K27 Trimethyltransferase Activity Nucleosome Binding Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Zinc Ion Binding
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