RAI1 and PEMT

		RAI1	PEMT
Description		retinoic acid induced 1	phosphatidylethanolamine N-methyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Phosphatidyl-N-methylethanolamine N-methyltransferase Activity Phosphatidylethanolamine N-methyltransferase Activity Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity
	Biological Process	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Negative Regulation Of Multicellular Organism Growth Positive Regulation Of DNA-templated Transcription Rhythmic Process	Blastocyst Hatching Lipid Metabolic Process Phosphatidylcholine Biosynthetic Process Sphingomyelin Biosynthetic Process Phospholipid Biosynthetic Process Methylation Positive Regulation Of Cold-induced Thermogenesis
Pathways		Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2	Synthesis of PC
Drugs
Diseases		Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
GWAS		A body shape index ( 34021172) Body mass index ( 28892062) Caffeine consumption from coffee ( 33287642) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Glycated hemoglobin levels ( 34059833) Hip circumference ( 25673412) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 27863252) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Parkinson's disease ( 21738487) Schizophrenia ( 29483656 28991256 25056061) Type 2 diabetes ( 30054458 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lipoprotein (a) levels ( 33730874) Mean spheric corpuscular volume ( 32888494) Obsessive-compulsive symptoms ( 26859814) Triglyceride levels ( 32154731 32203549) Triglycerides ( 30275531) Waist-hip index ( 34021172) Waist-hip ratio ( 28552196 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (recessive genetic model) ( 30778226) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		17 interacting genes: CASP2 CDKN1A DDIT3 GADD45A GATA1 GLI1 GSK3B LZTR1 MAML3 MAPK8IP2 PIN1 RPS6KA5 TESC TET2 TOPBP1 TTR ZNF496	4 interacting genes: AQP6 FCER1G SPP1 STOM
Entrez ID		10743	10400
HPRD ID		07406	03862
Ensembl ID		ENSG00000108557	ENSG00000133027
Uniprot IDs		Q7Z5J4	Q9UBM1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Positive Regulation Of RNA Metabolic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Transcription By RNA Polymerase II ER Overload Response RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Apoptotic Signaling Pathway Megakaryocyte Differentiation Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Cycle Regulation Of Canonical Wnt Signaling Pathway Nucleoplasm Regulation Of RNA Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Growth Intracellular Signaling Cassette Regeneration Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Response To Stress Response To Ionizing Radiation Regulation Of JNK Cascade Positive Regulation Of Biosynthetic Process Mitotic G2 DNA Damage Checkpoint Signaling Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Developmental Process ER-nucleus Signaling Pathway Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein	PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Nitrate Transmembrane Transport Carbon Dioxide Transmembrane Transport Tertiary Granule Membrane Vesicle Positive Regulation Of Type I Hypersensitivity Mast Cell Apoptotic Process Serotonin Secretion Negative Regulation Of Mast Cell Apoptotic Process IgE Receptor Activity Positive Regulation Of Type IIa Hypersensitivity Serotonin Secretion By Platelet Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Fc-gamma Receptor III Complex Fc-epsilon Receptor I Complex Positive Regulation Of Type III Hypersensitivity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Androgen Catabolic Process Negative Regulation Of Developmental Growth Negative Regulation Of Growth Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Cellular Response To Testosterone Stimulus Monoatomic Anion Channel Activity Renal Water Transport Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation Response To 2,3,7,8-tetrachlorodibenzodioxine Ammonium Channel Activity Response To Macrophage Colony-stimulating Factor Ammonium Transmembrane Transport Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Ion Channel Inhibitor Activity Positive Regulation Of Secretion Neutrophil Activation Involved In Immune Response IgG Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Secretion By Cell Serotonin Transport Positive Regulation Of Bone Resorption Regulation Of Developmental Growth Negative Regulation Of Collateral Sprouting
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