PEMT

Description		phosphatidylethanolamine N-methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane
	Molecular Function	Phosphatidyl-N-methylethanolamine N-methyltransferase Activity Phosphatidylethanolamine N-methyltransferase Activity Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity
	Biological Process	Blastocyst Hatching Lipid Metabolic Process Phosphatidylcholine Biosynthetic Process Sphingomyelin Biosynthetic Process Phospholipid Biosynthetic Process Methylation Positive Regulation Of Cold-induced Thermogenesis
Pathways		Synthesis of PC
Drugs
Diseases
GWAS		A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lipoprotein (a) levels ( 33730874) Mean spheric corpuscular volume ( 32888494) Obsessive-compulsive symptoms ( 26859814) Triglyceride levels ( 32154731 32203549) Triglycerides ( 30275531) Waist-hip index ( 34021172) Waist-hip ratio ( 28552196 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (recessive genetic model) ( 30778226) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Novel Interacting Genes		1 novel interacting genes: RAI1
Interacting Genes		4 interacting genes: AQP6 FCER1G SPP1 STOM
Entrez ID		10400
HPRD ID		03862
Ensembl ID		ENSG00000133027
Uniprot IDs		Q9UBM1
PDB IDs
Enriched GO Terms of Interacting Partners?		PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Nitrate Transmembrane Transport Carbon Dioxide Transmembrane Transport Tertiary Granule Membrane Vesicle Positive Regulation Of Type I Hypersensitivity Mast Cell Apoptotic Process Serotonin Secretion Negative Regulation Of Mast Cell Apoptotic Process IgE Receptor Activity Positive Regulation Of Type IIa Hypersensitivity Serotonin Secretion By Platelet Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Fc-gamma Receptor III Complex Fc-epsilon Receptor I Complex Positive Regulation Of Type III Hypersensitivity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Androgen Catabolic Process Negative Regulation Of Developmental Growth Negative Regulation Of Growth Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Cellular Response To Testosterone Stimulus Monoatomic Anion Channel Activity Renal Water Transport Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation Response To 2,3,7,8-tetrachlorodibenzodioxine Ammonium Channel Activity Response To Macrophage Colony-stimulating Factor Ammonium Transmembrane Transport Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Ion Channel Inhibitor Activity Positive Regulation Of Secretion Neutrophil Activation Involved In Immune Response IgG Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Secretion By Cell Serotonin Transport Positive Regulation Of Bone Resorption Regulation Of Developmental Growth Negative Regulation Of Collateral Sprouting
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