CD226 and GALR1

		CD226	GALR1
Description		CD226 molecule	galanin receptor 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Membrane Raft	Plasma Membrane Membrane
	Molecular Function	Integrin Binding Protein Binding Protein Kinase Binding Signaling Receptor Activity Identical Protein Binding Cell Adhesion Molecule Binding	G Protein-coupled Receptor Activity Galanin Receptor Activity Protein Binding Peptide Hormone Binding Neuropeptide Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Adhesion Signal Transduction Cell Recognition Positive Regulation Of Type II Interferon Production Positive Regulation Of Mast Cell Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cortisol Secretion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases		Type I diabetes mellitus
GWAS		Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic widespread musculoskeletal pain ( 33331911) Eosinophil count ( 32888494) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494 31194788 27863252 22139419 19820697) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 27992413 23603763) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 33272962) Type 1 diabetes ( 21829393 17554260 25751624) White blood cell count ( 32888494)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Blood osmolality (transformed sodium) ( 28360221) DHEAS levels ( 34748635) Height ( 31562340) Metabolite levels ( 31628463) Obesity-related traits ( 23251661) Smoking initiation (ever regular vs never regular) ( 31089300) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: FYN ITGB2 NECTIN2 PVR	2 interacting genes: GAL SNAPC5
Entrez ID		10666	2587
HPRD ID		09252	02657
Ensembl ID		ENSG00000150637	ENSG00000166573
Uniprot IDs		J3QR77 Q15762	P47211
PDB IDs		6ISB 6O3O	7WQ3 7XJJ
Enriched GO Terms of Interacting Partners?		Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Cell Adhesion Molecule Binding Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Protein Targeting To Membrane Negative Regulation Of Immune Response Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immune Response Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Immune Effector Process Negative Regulation Of Defense Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Innate Immune Response Regulation Of Natural Killer Cell Mediated Immunity Cellular Response To Glycine Response To Singlet Oxygen Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Regulation Of Immune Response Leukocyte Mediated Cytotoxicity Immune Effector Process Virus Receptor Activity Positive Regulation Of Immune System Process Focal Adhesion Response To Glycine Regulation Of Innate Immune Response Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Integrin AlphaL-beta2 Complex Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Sperm Mitochondrion Organization Positive Regulation Of Defense Response Regulation Of T Cell Mediated Immunity Cell-cell Adhesion Negative Regulation Of Hydrogen Peroxide Biosynthetic Process ICAM-3 Receptor Activity	Type 2 Galanin Receptor Binding Type 3 Galanin Receptor Binding Positive Regulation Of Large Conductance Calcium-activated Potassium Channel Activity Type 1 Galanin Receptor Binding Galanin Receptor Binding Transcription Initiation At RNA Polymerase III Promoter SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III RNA Polymerase III General Transcription Initiation Factor Activity Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Mast Cell Activation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Natural Killer Cell Cytokine Production Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Protein Kinase A Signaling Positive Regulation Of Timing Of Catagen Positive Regulation Of Hair Follicle Development Positive Regulation Of Cortisol Secretion Galanin Receptor Activity Regulation Of Glucocorticoid Metabolic Process Regulation Of Timing Of Catagen SnRNA Transcription Parental Behavior Positive Regulation Of Immune Response To Tumor Cell Regulation Of Mast Cell Activation Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Hair Follicle Development Regulation Of Cell Activation Response To Immobilization Stress Positive Regulation Of Cation Channel Activity Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Neuropeptide Hormone Activity Regulation Of Hair Cycle Transcription By RNA Polymerase III Reproductive Behavior Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport Regulation Of Hormone Metabolic Process Positive Regulation Of Natural Killer Cell Mediated Immunity RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Immunoglobulin Mediated Immune Response Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Transporter Activity Natural Killer Cell Mediated Immunity Insulin Secretion
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