GALR1 and GAL

Number of citations of the paper that reports this interaction (PMID 7524088)
27

Data Source:
HPRD (in vitro, in vivo)

		GALR1	GAL
Gene Name		galanin receptor 1	galanin/GMAP prepropeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Golgi Apparatus Secretory Granule Neuronal Cell Body
	Molecular Function	Galanin Receptor Activity Protein Binding Peptide Hormone Binding Neuropeptide Binding	Neuropeptide Hormone Activity Protein Binding Type 1 Galanin Receptor Binding Type 2 Galanin Receptor Binding Type 3 Galanin Receptor Binding
	Biological Process	Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Digestion Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cortisol Secretion	Inflammatory Response Neuropeptide Signaling Pathway Nervous System Development Feeding Behavior Protein Kinase A Signaling CAMP-mediated Signaling Insulin Secretion Regulation Of Glucocorticoid Metabolic Process Response To Insulin Response To Immobilization Stress Response To Drug Positive Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Lymphocyte Proliferation Positive Regulation Of Cortisol Secretion Positive Regulation Of Catagen Positive Regulation Of Large Conductance Calcium-activated Potassium Channel Activity Negative Regulation Of Root Hair Elongation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		1 interactors: GAL	4 interactors: GALR1 GALR2 GPR151 SGTA
Entrez ID		2587	51083
HPRD ID		02657	00658
Ensembl ID			ENSG00000069482
Uniprot IDs		P47211	P22466
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Root Hair Elongation Positive Regulation Of Large Conductance Calcium-activated Potassium Channel Activity Positive Regulation Of Catagen Positive Regulation Of Cortisol Secretion Negative Regulation Of Lymphocyte Migration Protein Kinase A Signaling Positive Regulation Of Hair Follicle Development Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Glucocorticoid Metabolic Process Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Hair Follicle Development Negative Regulation Of Leukocyte Migration CAMP-mediated Signaling Regulation Of Hair Cycle Response To Immobilization Stress Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport Cyclic-nucleotide-mediated Signaling Regulation Of Lymphocyte Migration Positive Regulation Of Epidermis Development Positive Regulation Of Cation Channel Activity Regulation Of Hormone Metabolic Process Regulation Of Potassium Ion Transmembrane Transport Insulin Secretion Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Positive Regulation Of Lipid Transport Regulation Of Potassium Ion Transport Peptide Hormone Secretion Regulation Of Epidermis Development Peptide Secretion Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of Ion Transmembrane Transport Regulation Of Cation Channel Activity Hormone Secretion Negative Regulation Of Developmental Growth Hormone Transport Regulation Of Lipid Transport Peptide Transport Neuropeptide Signaling Pathway Regulation Of Steroid Metabolic Process Feeding Behavior Positive Regulation Of Hormone Secretion Regulation Of Leukocyte Migration Protein Secretion Amide Transport Negative Regulation Of Lymphocyte Activation	Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Neuropeptide Signaling Pathway Regulation Of CAMP Metabolic Process Digestion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Large Conductance Calcium-activated Potassium Channel Activity Cytosolic Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cortisol Secretion Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Positive Regulation Of Potassium Ion Transmembrane Transport Cellular Chemical Homeostasis Ion Homeostasis Synaptic Transmission Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport Cellular Homeostasis Positive Regulation Of Transport Positive Regulation Of Cation Channel Activity Negative Regulation Of Catalytic Activity Regulation Of Potassium Ion Transmembrane Transport Chemical Homeostasis Cell Surface Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Ion Transmembrane Transporter Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Transporter Activity Positive Regulation Of Lipid Transport Regulation Of Potassium Ion Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ion Transmembrane Transport Regulation Of Cation Channel Activity Regulation Of Lipid Transport Feeding Behavior Positive Regulation Of Transcription, DNA-templated
Tagcloud ?		2specific antitumor benefits caspase3dependent cki cyclindependent d1 decreasing erk1 exerts extracellularregulated galanin galr2 galr2negative galr2transfected head hnscc kinase1 ladder neck pertussis pretreatment reactivation reexpression suppressed suppresses suppressors toxin u0126	asialoglycoprotein asialoorosomucoid chromatographed competed crosslinked crosslinking crossreacted deglycosylated dithiobis dtssp egta exoglycosidases ghosts glycosidase hepatocytes lactose leu121 lf lfs lys126 lys220 neunac p45 phe198 rhl stripped sulfosuccimidylproprionate triton vigorously
Tagcloud (Difference) ?		2specific antitumor benefits caspase3dependent cki cyclindependent d1 decreasing erk1 exerts extracellularregulated galanin galr2 galr2negative galr2transfected head hnscc kinase1 ladder neck pertussis pretreatment reactivation reexpression suppressed suppresses suppressors toxin u0126	asialoglycoprotein asialoorosomucoid chromatographed competed crosslinked crosslinking crossreacted deglycosylated dithiobis dtssp egta exoglycosidases ghosts glycosidase hepatocytes lactose leu121 lf lfs lys126 lys220 neunac p45 phe198 rhl stripped sulfosuccimidylproprionate triton vigorously
Tagcloud (Intersection) ?