GNLY and DERL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GNLY	DERL3
Description		granulysin	derlin 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytolytic Granule Phagocytic Vesicle Lumen	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Signal Recognition Particle Binding Protein Binding Protein-containing Complex Binding
	Biological Process	Cellular Defense Response Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Fungus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Protein N-linked Glycosylation Via Asparagine Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Antimicrobial peptides	ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs		3-(N-morpholino)propanesulfonic acid
Diseases
GWAS			Ejection fraction ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Left ventricular internal dimension in systole ( 29403010) PR interval ( 32439900) S-phenylmercapturic acid levels in smokers ( 26959369)
Interacting Genes		4 interacting genes: APP BCL2L1 DERL3 FBXO7	19 interacting genes: EHHADH GAD2 GNLY GPR101 IL27RA MELTF NDRG4 PSCA RTP4 SDCBP SERPINA1 SLC13A4 STATH SYT16 TEX29 TMEM179B TMEM31 TMEM92 ULBP2
Entrez ID		10578	91319
HPRD ID		01788	13139
Ensembl ID		ENSG00000115523	ENSG00000099958
Uniprot IDs		B4E3H9 P22749	Q96Q80
PDB IDs		1L9L
Enriched GO Terms of Interacting Partners?		Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization Regulation Of Neuron Apoptotic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Apoptotic Process In Bone Marrow Cell Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Localization Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Lewy Body Core Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Cell Cycle Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Response To Cycloheximide Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway
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