DERL3 and RTP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DERL3	RTP4
Description		derlin 3	receptor transporter protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm Membrane
	Molecular Function	Signal Recognition Particle Binding Protein Binding Protein-containing Complex Binding	Protein Binding Zinc Ion Binding Olfactory Receptor Binding Metal Ion Binding
	Biological Process	Protein N-linked Glycosylation Via Asparagine Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Protein Targeting To Membrane Protein Insertion Into Membrane Defense Response To Virus
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Ejection fraction ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Left ventricular internal dimension in systole ( 29403010) PR interval ( 32439900) S-phenylmercapturic acid levels in smokers ( 26959369)	Impulsivity (attentional) ( 30718321)
Interacting Genes		19 interacting genes: EHHADH GAD2 GNLY GPR101 IL27RA MELTF NDRG4 PSCA RTP4 SDCBP SERPINA1 SLC13A4 STATH SYT16 TEX29 TMEM179B TMEM31 TMEM92 ULBP2	5 interacting genes: DERL3 OPRM1 REEP4 TAS2R10 TRARG1
Entrez ID		91319	64108
HPRD ID		13139	17136
Ensembl ID		ENSG00000099958	ENSG00000136514
Uniprot IDs		Q96Q80	Q96DX8
PDB IDs
Enriched GO Terms of Interacting Partners?			Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Transport Cellular Response To Morphine Regulation Of NMDA Receptor Activity Behavioral Response To Ethanol Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Opioid Receptor Activity G Protein-coupled Opioid Receptor Signaling Pathway Negative Regulation Of Protein Localization Taste Receptor Activity Bitter Taste Receptor Activity Mitotic Nuclear Membrane Reassembly Signal Recognition Particle Binding Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Protein Exit From Endoplasmic Reticulum Glucose Import In Response To Insulin Stimulus Vesicle Fusion To Plasma Membrane Endoplasmic Reticulum Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Transport G Protein-coupled Receptor Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Cytosolic Calcium Ion Concentration Response To Morphine Regulation Of Protein Transport Regulation Of Neurotransmitter Receptor Activity G-protein Beta-subunit Binding Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Protein N-linked Glycosylation Via Asparagine Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Retrograde Protein Transport, ER To Cytosol Endosome To Plasma Membrane Protein Transport D-glucose Import Nuclear Envelope Organization Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Sensory Perception Nuclear Membrane Reassembly Neuropeptide Binding D-glucose Transmembrane Transport G-protein Alpha-subunit Binding Regulation Of Establishment Of Protein Localization Voltage-gated Calcium Channel Activity Sensory Perception Of Taste Hexose Transmembrane Transport Regulation Of Signaling Receptor Activity
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