ARFGEF2 and SLC9A8

		ARFGEF2	SLC9A8
Description		ARF guanine nucleotide exchange factor 2	solute carrier family 9 member A8
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Axonemal Microtubule Membrane Dendrite Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Cell Projection Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Golgi Membrane Acrosomal Vesicle Endosome Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Multivesicular Body Membrane Trans-Golgi Network Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding	Protein Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity
	Biological Process	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction	Acrosome Assembly Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Regulation Of PH Spermatogenesis Cell Differentiation Sodium Ion Transmembrane Transport Regulation Of Intracellular PH Transmembrane Transport Potassium Ion Transmembrane Transport Proton Transmembrane Transport Regulation Of Golgi Lumen Acidification
Pathways		Association of TriC/CCT with target proteins during biosynthesis	Sodium/Proton exchangers
Drugs
Diseases		Periventricular nodular heterotopia (PVNH)
GWAS		Adult body size ( 32376654) Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 29212778) Early cardiac repolarization ( 31600170) Gut microbiota (beta diversity) ( 27723756) Multiple sclerosis ( 24076602) Psoriasis ( 20953189)
Interacting Genes		10 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 LCOR PNPLA2 PRKAR1A PRKAR2A PRPF40A	1 interacting genes: MEOX2
Entrez ID		10564	23315
HPRD ID		09250	18062
Ensembl ID		ENSG00000124198	ENSG00000197818
Uniprot IDs		A0A7P0T7Z2 Q59FR3 Q86TH5 Q9Y6D5	B4DIX7 Q9Y2E8
PDB IDs		3L8N 3SWV
Enriched GO Terms of Interacting Partners?		Cellular Response To Histamine Response To Histamine GABA-A Receptor Activity GABA-gated Chloride Ion Channel Activity GABA-A Receptor Complex Gamma-aminobutyric Acid Signaling Pathway Postsynaptic Specialization Membrane Synaptic Transmission, GABAergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Chloride Channel Complex CAMP-dependent Protein Kinase Regulator Activity Chloride Channel Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Inner Ear Receptor Cell Development Chloride Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Protein Kinase A Catalytic Subunit Binding GABA-ergic Synapse Chloride Transport Inorganic Anion Transmembrane Transport Regulation Of Biological Quality Innervation CAMP Binding Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Inhibitory Synapse Assembly Negative Regulation Of CAMP/PKA Signal Transduction Monoatomic Ion Channel Activity Neuron Development Cochlea Development Plasma Membrane Raft Membrane Ciliary Base Transmembrane Signaling Receptor Activity Regulation Of CAMP/PKA Signal Transduction Postsynaptic Membrane Transmembrane Transport Circadian Sleep/wake Cycle, REM Sleep Prostaglandin-I Synthase Activity Inorganic Ion Transmembrane Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Regulation Of Cytokinesis	Adenylyltransferase Activity Molybdopterin-synthase Adenylyltransferase Activity URM1 Activating Enzyme Activity Molybdopterin-synthase Sulfurtransferase Activity Somite Specification Symmetric Synapse Endomembrane System Organization Molybdopterin Cofactor Metabolic Process TRNA Thio-modification TRNA Wobble Position Uridine Thiolation Protein Urmylation Mo-molybdopterin Cofactor Biosynthetic Process Thiosulfate-cyanide Sulfurtransferase Activity Molybdopterin Cofactor Biosynthetic Process Sulfurtransferase Activity Ubiquitin-like Modifier Activating Enzyme Activity Asymmetric Synapse Segment Specification Somite Development TRNA Wobble Uridine Modification GABA Receptor Binding Regulation Of ARF Protein Signal Transduction Protein Kinase A Regulatory Subunit Binding Myosin Binding Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Receptor Recycling Axonemal Microtubule
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