OLFM4 and PCDH17

		OLFM4	PCDH17
Description		olfactomedin 4	protocadherin 17
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Mitochondrion Cytosol Plasma Membrane Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Azurophil Granule Intercellular Bridge Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Lumen	Plasma Membrane Membrane Presynaptic Membrane Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Structural Molecule Activity Protein Binding Cadherin Binding	Calcium Ion Binding Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Immune Response Cell Adhesion Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Immune Response Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Adult Behavior Negative Regulation Of Synaptic Transmission Synaptic Membrane Adhesion Presynaptic Active Zone Assembly Regulation Of Synaptic Vesicle Clustering
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 24861553 25673413 25953783 28448500 26961502) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Childhood body mass index ( 26604143) Depression ( 29700475) Hip circumference ( 25673412) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Multisite chronic pain ( 33830993) Obesity ( 23563607 22484627) Obesity-related traits ( 23251661) Waist circumference ( 25673412)	Adult body size ( 32376654) Body mass index ( 25673413) Body size at age 10 ( 32376654) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 25644384) Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Experiencing mood swings ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Regular attendance at a religious group ( 29970889) Subcutaneous adipose tissue ( 26480920 22589738) Type 2 diabetes ( 30297969)
Interacting Genes		36 interacting genes: APP AQP2 AQP3 BSCL2 C3 CFTR CLDN7 CLEC17A CLEC7A CLSTN3 CLTRN CREB3L1 EREG FAM209A FNDC9 IL11RA ITM2C KASH5 KIR2DL3 KIR3DL3 LDLRAD1 LEUTX LHFPL2 PVR PVRIG QPCTL SAR1A SLC18A1 SLC22A23 SUSD3 SYNE4 TFR2 TMEM130 TNFSF11 TNFSF14 TSPAN18	6 interacting genes: NR1H2 SIAH1 TSC22D4 UBQLN4 YAF2 ZP3
Entrez ID		10562	27253
HPRD ID		06580	15104
Ensembl ID		ENSG00000102837	ENSG00000118946
Uniprot IDs		Q6UX06	O14917
PDB IDs			6VFT
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Receptor Ligand Activity Multicellular Organismal-level Chemical Homeostasis Water Transport Multicellular Organismal-level Water Homeostasis Fluid Transport Glycerol Transmembrane Transport Multicellular Organismal-level Homeostasis Renal Water Transport Polyol Transmembrane Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Yeast Cell Maturation Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Neuron Remodeling Water Channel Activity Organic Hydroxy Compound Transport Positive Regulation Of Defense Response Cell Surface Regulation Of Immune System Process Renal Water Homeostasis	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of DNA-templated Transcription Positive Regulation Of High-density Lipoprotein Particle Assembly Regulation Of High-density Lipoprotein Particle Assembly Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Pancreatic Juice Secretion Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Type IV Hypersensitivity Egg Coat Formation Positive Regulation Of Antral Ovarian Follicle Growth Structural Constituent Of Egg Coat Regulation Of Acrosomal Vesicle Exocytosis Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Apolipoprotein A-I Receptor Binding Acrosin Binding Negative Regulation Of Binding Of Sperm To Zona Pellucida Egg Coat Regulation Of Type IV Hypersensitivity Negative Regulation Of Metabolic Process Negative Regulation Of Pinocytosis Regulation Of Binding Of Sperm To Zona Pellucida Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Ovarian Follicle Development Cytosolic Proteasome Complex Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Hypersensitivity Negative Regulation Of Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Acrosome Reaction Negative Regulation Of Cholesterol Storage K48-linked Polyubiquitin Modification-dependent Protein Binding
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