SLC19A2 and CERS2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SLC19A2	CERS2
Gene Name		solute carrier family 19 (thiamine transporter), member 2	ceramide synthase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Protein Binding Folic Acid Transporter Activity Thiamine Transmembrane Transporter Activity Thiamine Uptake Transmembrane Transporter Activity	DNA Binding Protein Binding Sphingosine N-acyltransferase Activity
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Folic Acid Transport Thiamine Transport Thiamine-containing Compound Metabolic Process Small Molecule Metabolic Process Thiamine Transmembrane Transport	Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Small Molecule Metabolic Process Ceramide Biosynthetic Process
Pathways		Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Vitamin B1 (thiamin) metabolism Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism	Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Venous thromboembolism ( 21980494)	Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		1 interactors: CERS2	9 interactors: ASGR1 ASGR2 ATP6V0C HSP90AA1 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6
Entrez ID		10560	29956
HPRD ID		04897	06080
Ensembl ID		ENSG00000117479	ENSG00000143418
Uniprot IDs		O60779	Q96G23
PDB IDs
Enriched GO Terms of Interacting Partners?		Ceramide Biosynthetic Process Sphingolipid Biosynthetic Process Ceramide Metabolic Process Sphingolipid Metabolic Process Membrane Lipid Metabolic Process	Transmembrane Transport Transport Drug Transmembrane Transport Drug Transport Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Receptor-mediated Endocytosis Epinephrine Transport Response To Unfolded Protein Protein Import Into Peroxisome Matrix, Translocation Acetate Ester Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Protein Stability Protein Import Into Mitochondrial Outer Membrane Norepinephrine Transport Protein Import Endocytosis Thiamine Transmembrane Transport Thiamine Transport Thiamine-containing Compound Metabolic Process Ion Transport Folic Acid Transport Chemical Homeostasis Dopamine Transport Cation Transmembrane Transport Chaperone-mediated Protein Complex Assembly Protein Import Into Peroxisome Matrix Pyrimidine-containing Compound Transmembrane Transport Quaternary Ammonium Group Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle Protein Refolding Vitamin Transmembrane Transport Cation Transport Zinc Ion Transmembrane Transport Cellular Metal Ion Homeostasis Monoamine Transport Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Response To Stimulus Protein Targeting Ion Transmembrane Transport Nitric Oxide Metabolic Process Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Cation Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Cellular Response To Heat Cellular Ion Homeostasis Reactive Nitrogen Species Metabolic Process Posttranscriptional Regulation Of Gene Expression
Tagcloud ?			17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Difference) ?			17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Intersection) ?