SPTLC1 and GTF2IRD1

Number of citations of the paper that reports this interaction (PubMedID 26275350)
0

Data Source:
BioGRID (two hybrid)

		SPTLC1	GTF2IRD1
Description		serine palmitoyltransferase long chain base subunit 1	GTF2I repeat domain containing 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	Serine C-palmitoyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Amide Biosynthetic Process Sphinganine Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Positive Regulation Of Lipophagy Regulation Of Fat Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Transition Between Slow And Fast Fiber
Pathways		Sphingolipid de novo biosynthesis
Drugs		Pyridoxal phosphate Serine
Diseases
GWAS		Bipolar disorder and schizophrenia ( 22688191) Left inferior lateral ventricle volume (Cerebrospinal fluid biomarker status interaction) ( 25140149) Serum immune biomarker levels ( 32066700)	Age at suicide ( 31476763) Aluminium levels ( 26025379) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Rheumatoid arthritis ( 32723749) Severe influenza A (H1N1) infection ( 26379185) Sjögren's syndrome ( 24097066) Systemic lupus erythematosus ( 26663301 28714469) Triglyceride levels ( 32203549)
Interacting Genes		3 interacting genes: ABCA1 GTF2IRD1 SPTLC2	24 interacting genes: ALMS1 ATP2C1 CDK20 DCAF6 EXOSC4 GORASP2 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 MRFAP1L1 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5
Entrez ID		10558	9569
HPRD ID		05754	08379
Ensembl ID		ENSG00000090054	ENSG00000006704
Uniprot IDs		O15269 Q6NUL7	E9PFE2 Q9UHL9
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0I 7K0J 7K0K 7K0L 7K0M 7K0N 7K0O 7K0P 7K0Q 7YIU 7YIY 7YJ1 7YJ2	2D99 2DN5 2DZQ 2DZR
Enriched GO Terms of Interacting Partners?		Response To Vitamin B3 Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Sphingolipid Floppase Activity Sphinganine Biosynthetic Process Sphinganine Metabolic Process G Protein-coupled GABA Receptor Complex G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Heterodimeric Complex Transition Between Slow And Fast Fiber Apolipoprotein A-I-mediated Signaling Pathway Floppase Activity Regulation Of High-density Lipoprotein Particle Assembly Sphingolipid Translocation Apolipoprotein A-I Binding Phosphatidylserine Floppase Activity Positive Regulation Of Lipophagy Serine C-palmitoyltransferase Activity GABA Receptor Complex Neuron-glial Cell Signaling Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Lipoprotein Biosynthetic Process Phosphatidylcholine Floppase Activity GABA Receptor Activity Serine Palmitoyltransferase Complex High-density Lipoprotein Particle Assembly Alcohol Metabolic Process High-density Lipoprotein Particle Binding ATPase-coupled Intramembrane Lipid Transporter Activity Negative Regulation Of Cholesterol Storage Sphingomyelin Biosynthetic Process Negative Regulation Of Adenylate Cyclase Activity Regulation Of Skeletal Muscle Adaptation Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of Macrophage Derived Foam Cell Differentiation Sphingosine Biosynthetic Process Sphingoid Biosynthetic Process Phospholipid Homeostasis Phospholipid Transporter Activity Apolipoprotein Binding Reverse Cholesterol Transport Cellular Response To Cholesterol Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Defense Response To Virus Sphingosine Metabolic Process Cellular Response To Sterol Intracellular Vesicle Sphingomyelin Metabolic Process Intracellular Cholesterol Transport	NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Viral Penetration Into Host Nucleus Protein Import Into Nucleus Import Into Nucleus Intermediate Filament Binding Intracellular Transport Of Virus Intermediate Filament Bundle Assembly Desmosome Assembly Nucleoplasm Host Cell Protein Localization To Nucleus SUMO Ligase Activity Positive Regulation Of Protein Localization To Cell Periphery Desmosome Organization Nuclear Pore Ubiquitin-specific Protease Binding Positive Regulation Of Protein Localization SUMO Transferase Activity Nuclear Transport Nucleocytoplasmic Transport SMAD Protein Signal Transduction Desmosome Ubiquitin Protein Ligase Binding Intracellular Protein Transport Cellular Localization Collagen Type XV Trimer Establishment Of Protein Localization To Organelle Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Cell Periphery Maintenance Of Protein Localization At Cell Tip Positive Regulation Of Ferroptosis
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