FAM3C and KIR2DL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM3C	KIR2DL3
Description		FAM3 metabolism regulating signaling molecule C	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Platelet Dense Granule Lumen Cytoplasmic Vesicle Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Protein Binding Carbohydrate Binding	Antigen Binding Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Inflammatory Response Epidermal Cell Differentiation Gene Expression Neutrophil Differentiation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Keratinocyte Proliferation ERK1 And ERK2 Cascade	Immune Response-regulating Signaling Pathway Immune Response
Pathways		Platelet degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Biomedical quantitative traits ( 19396169) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Calcaneus stiffness index ( 30779856) Forearm bone mineral density ( 26367794) Hand grip strength ( 27325353) Heel bone mineral density ( 28869591 30598549) Lung adenocarcinoma ( 28604730) Pediatric bone mineral content (radius) ( 26041818) Phenylephrine infusion rate during anesthesia ( 31455332) Total body bone mineral density ( 30172743) Ulna and radius bone mineral density ( 30172743)
Interacting Genes		50 interacting genes: AHNAK2 BIK BNIP2 CLEC17A CLEC2D CLEC4E CREB3 CREB3L1 CXADR CYB5R3 ELOVL4 ERGIC3 EVI2B FAM209A FCGR1A FCGRT FFAR2 FKBP7 GGT6 GJB5 GOLPH3 GOLPH3L GPR42 GPX8 HHLA2 KCNA2 KIR2DL3 LMNA LRRC25 MFF PDZK1IP1 RELL2 RMDN3 RNASEH1 SAR1A SCN3B SLC10A6 SLC16A2 SLC18A1 SLC35H1 SPINT1 SSMEM1 STX1A TEX29 TMEM248 TMEM45B TMEM71 TMEM80 TMPRSS2 TMX2	64 interacting genes: ADGRE2 AGTRAP AIG1 ANKRD46 APOA2 APOD APP AQP10 ASGR1 ATP6V0E1 BMP10 BRICD5 BTN2A2 C3orf52 CDIPT CISD2 CLDN19 CLN6 COQ9 CXCL16 CXCL9 CYB5B CYBC1 EMD FAM209A FAM3C FUNDC2 GAST GJA8 GPR108 GPX8 HLA-C IFITM3 INSIG2 ITGAM JAGN1 KTN1 LAT LCK LEUTX LHFPL5 NINJ2 NRM NSG1 OLFM4 PLN PLPPR2 PTPN6 RNF152 RTP2 SEC22B SLC38A7 SMIM1 SNORC THBD TMEM218 TMEM222 TMEM243 TMEM86B TMEM97 TRAF3IP3 UPK1B UPK2 VAMP5
Entrez ID		10447	3804
HPRD ID		12270	10383
Ensembl ID		ENSG00000196937	ENSG00000243772
Uniprot IDs		Q92520	E3NZD8 P43628
PDB IDs		5LC2	1B6U 6PAG 8TUI
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Protein Targeting To Golgi Apparatus Golgi Vesicle Budding Cargo Adaptor Activity	Membrane Protein Binding Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cholesterol Binding CD27 Signaling Pathway
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