LYPLA1 and ANXA2

Number of citations of the paper that reports this interaction (PMID 1531641)
1

Data Source:
HPRD (in vivo, in vitro)

		LYPLA1	ANXA2
Gene Name		lysophospholipase I	annexin A2
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Extracellular Vesicular Exosome	Ruffle Basement Membrane Extracellular Space Nucleus Lysosomal Membrane Endosome Early Endosome Lipid Particle Plasma Membrane Cell Cortex Cell Surface Membrane Extrinsic Component Of Plasma Membrane Midbody Extracellular Matrix Late Endosome Membrane Vesicle Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Protein Complex Macropinosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Lysophospholipase Activity Palmitoyl-(protein) Hydrolase Activity	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Rab GTPase Binding Phospholipase A2 Inhibitor Activity S100 Protein Binding Poly(A) RNA Binding Calcium-dependent Protein Binding
	Biological Process	Protein Depalmitoylation Fatty Acid Metabolic Process Negative Regulation Of Golgi To Plasma Membrane Protein Transport Small Molecule Metabolic Process Nitric Oxide Metabolic Process Regulation Of Nitric-oxide Synthase Activity	Angiogenesis Membrane Raft Assembly Positive Regulation Of Protein Phosphorylation Membrane Budding Body Fluid Secretion Collagen Fibril Organization Positive Regulation Of Vesicle Fusion Osteoclast Development Fibrinolysis Negative Regulation Of Catalytic Activity Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Binding Protein Heterotetramerization Protein Targeting To Plasma Membrane
Pathways		eNOS activation Metabolism of nitric oxide eNOS activation and regulation	Dissolution of Fibrin Clot Orphan transporters
Drugs			Tenecteplase
Diseases
GWAS
Protein-Protein Interactions		2 interactors: ANXA2 GOLGA2	31 interactors: APOH APP CD99 CDC42 CEACAM1 CTSB DYSF GRB2 HMGA1 LGALS13 LYPLA1 MAP3K4 MYOC PHB PLA1A PLAT PLG POT1 PRKCA PRKCB S100A10 S100A4 S100A6 SOS1 SRC STAT6 TERF1 TERT TP53 TRPV5 YWHAQ
Entrez ID		10434	302
HPRD ID		07063	01061
Ensembl ID		ENSG00000120992	ENSG00000182718
Uniprot IDs		B4DP64 O75608 Q6IAQ1	P07355
PDB IDs		1FJ2	1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4HRH
Enriched GO Terms of Interacting Partners?		Regulation Of Binding Osteoclast Development Membrane Raft Assembly Protein Heterotetramerization Fibrinolysis Membrane Raft Organization Positive Regulation Of Vesicle Fusion Membrane Assembly Membrane Biogenesis Protein Targeting To Plasma Membrane Regulation Of Vesicle Fusion Negative Regulation Of Blood Coagulation Osteoclast Differentiation Negative Regulation Of Coagulation Collagen Fibril Organization Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Wound Healing Negative Regulation Of Protein Binding Establishment Of Protein Localization To Plasma Membrane Membrane Budding Regulation Of Fibroblast Proliferation Regulation Of Blood Coagulation Body Fluid Secretion Negative Regulation Of Binding Protein Tetramerization Positive Regulation Of Binding Myeloid Leukocyte Differentiation Regulation Of Wound Healing Protein Heterooligomerization Protein Localization To Plasma Membrane Regulation Of Protein Binding Protein Targeting To Membrane	Blood Coagulation Hemostasis Wound Healing Response To Wounding Regulation Of Body Fluid Levels Platelet Activation Positive Regulation Of Cellular Component Biogenesis Leukocyte Migration Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization ERBB Signaling Pathway Cell Activation Regulation Of Signaling Telomere Maintenance Via Telomerase Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Developmental Process Regulation Of Apoptotic Process Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Histone H3-T6 Phosphorylation Cellular Component Assembly Regulation Of Cell Death Epidermal Growth Factor Receptor Signaling Pathway Cell Aging Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity RNA-dependent DNA Replication Regulation Of ERBB Signaling Pathway Age-dependent Telomere Shortening Telomere Formation Via Telomerase Regulation Of Cell-substrate Adhesion Negative Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Innate Immune Response Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Adhesion Immune System Process Cell Migration Regulation Of Blood Coagulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Membrane Organization
Tagcloud ?		abpp advance campaign carbamate depalmitoylation dual fluopol hras hts irreversible micromolar ml211 ml348 ml349 ml378 optimized owing palmitoyl palmitoylation polarization sar scaffold seeking solubility thioesterase triazole	annexin apoptotic biological biomarker candidate collectively contributes encoding fully gemcitabine herein intracellular kappab localization mediates mia nf nucleus p50 paca2 pancreatic resting suppresses translocated understood upregulated upregulation y23a
Tagcloud (Difference) ?		abpp advance campaign carbamate depalmitoylation dual fluopol hras hts irreversible micromolar ml211 ml348 ml349 ml378 optimized owing palmitoyl palmitoylation polarization sar scaffold seeking solubility thioesterase triazole	annexin apoptotic biological biomarker candidate collectively contributes encoding fully gemcitabine herein intracellular kappab localization mediates mia nf nucleus p50 paca2 pancreatic resting suppresses translocated understood upregulated upregulation y23a
Tagcloud (Intersection) ?