LYPLA1

Description		lysophospholipase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Nuclear Membrane Extracellular Exosome
	Molecular Function	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Protein Binding Palmitoyl-(protein) Hydrolase Activity Lipase Activity Hydrolase Activity
	Biological Process	Protein Depalmitoylation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Transport Aggrephagy Negative Regulation Of Golgi To Plasma Membrane Protein Transport Protein Targeting To Vacuole Involved In Autophagy Negative Regulation Of Aggrephagy
Pathways		eNOS activation RAS processing
Drugs
Diseases
GWAS		Itch intensity from mosquito bite adjusted by bite size ( 28199695) Pelvic organ prolapse (moderate/severe) ( 26545240) Urinary albumin-to-creatinine ratio ( 26631737) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
Novel Interacting Genes		2 novel interacting genes: PIK3CA PLOD2
Interacting Genes		3 interacting genes: ANXA2 GOLGA2 SFMBT2
Entrez ID		10434
HPRD ID		07063
Ensembl ID		ENSG00000120992
Uniprot IDs		A0A087X1K9 B4DP64 O75608 Q6IAQ1
PDB IDs		1FJ2 5SYM 6QGN 6QGO 6QGQ 6QGS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Collagen Fibril Organization Positive Regulation Of Low-density Lipoprotein Particle Clearance Extracellular Matrix Organization Regulation Of Plasma Membrane Repair Osteoclast Development Regulation Of Intracellular Cholesterol Transport Positive Regulation Of Plasma Membrane Repair AnxA2-p11 Complex Positive Regulation Of Intracellular Lipid Transport PCSK9-AnxA2 Complex Regulation Of Intracellular Lipid Transport Extracellular Structure Organization Phospholipase A2 Inhibitor Activity Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Catabolic Process Phospholipase Inhibitor Activity Response To Activity Positive Regulation Of Plasminogen Activation Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Intracellular Cholesterol Transport Myelin Sheath Adaxonal Region Positive Regulation Of Protein Glycosylation Regulation Of Protein Glycosylation Negative Regulation Of Autophagy Importin-alpha Family Protein Binding Golgi Disassembly Autosome Genomic Imprinting Response To Muscle Inactivity Phosphatidylinositol 3-kinase Complex, Class IB Response To Butyrate Cardiac Muscle Cell Contraction Phosphatidylinositol 3-kinase Complex 1-phosphatidylinositol-4-phosphate 3-kinase Activity Cellular Response To Hydrostatic Pressure Negative Regulation Of Fibroblast Apoptotic Process Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Response To Hydrostatic Pressure Procollagen Glucosyltransferase Activity Rough Endoplasmic Reticulum Membrane Peptidyl-lysine Hydroxylation Hydroxylysine Biosynthetic Process Procollagen-lysine 5-dioxygenase Activity Negative Regulation Of Metabolic Process Golgi Ribbon Formation 1-phosphatidylinositol-3-kinase Activity Schmidt-Lanterman Incisure Angiogenesis
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