TUBB3 and PIEZO1

		TUBB3	PIEZO1
Description		tubulin beta 3 class III	piezo type mechanosensitive ion channel component 1 (Er blood group)
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Lamellipodium Filopodium Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body Intercellular Bridge Extracellular Exosome Cell Periphery Mitotic Spindle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Lamellipodium Membrane Stereocilium Cuticular Plate Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cell Projection
	Molecular Function	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Peptide Binding Metal Ion Binding Netrin Receptor Binding	Monoatomic Cation Channel Activity Protein Binding Mechanosensitive Monoatomic Ion Channel Activity Mechanosensitive Monoatomic Cation Channel Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Axon Guidance Neuron Differentiation Netrin-activated Signaling Pathway Dorsal Root Ganglion Development	Monoatomic Ion Transport Monoatomic Cation Transport Positive Regulation Of Myotube Differentiation Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Detection Of Mechanical Stimulus Cellular Response To Mechanical Stimulus Monoatomic Cation Transmembrane Transport
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Epothilone D Patupilone Ixabepilone CYT997 ZEN-012 Phenethyl Isothiocyanate
Diseases		Congenital fibrosis of the extraocular muscles (CFEOM)
GWAS		Brain morphology (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Squamous cell carcinoma ( 31174203)	Appendicular lean mass ( 33097823) Diverticular disease ( 30177863) Glycated hemoglobin levels ( 34059833) Hair color ( 26926045) Heel bone mineral density ( 30598549) Height ( 28552196 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 29403010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Joint mobility (Beighton score) ( 27182965) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010 28453575 27863252 32888494) Mean corpuscular volume ( 27863252 32888494 29403010) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494) Remission after antidepressant treatment in major depression ( 33589590) Response to antidepressants (symptom improvement) ( 33589590) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Triglyceride levels in HIV infection ( 33109212) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		38 interacting genes: ABCC2 ANXA7 ARHGEF7 CAMSAP3 CDC42 CDKN1A DDX39B DUX4 EEF1G GABARAP GZMK HEXD INSM1 KHDRBS1 LAPTM4A LIG1 LINC01554 MAP7D3 MAPT MRPL28 MTCL1 MTDH OGT PHIP PLK1 RCC1 RILPL2 ROBO1 RSPH1 SCGN SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE WEE2-AS1	1 interacting genes: FBXO7
Entrez ID		10381	9780
HPRD ID		04044	10945
Ensembl ID		ENSG00000258947	ENSG00000103335
Uniprot IDs		Q13509 Q53G92	Q92508
PDB IDs		5IJ0 5IJ9 5JCO 6E7B 6S8L 6WSL 7LXB 7M18 7M20 7PJF 7SJ7 7SJ8 7SJ9 7SJA 7Z6S 8VRJ 8VRK 8VT7	8YEZ 8YFC 8YFG 8ZU3 8ZU8
Enriched GO Terms of Interacting Partners?		Microtubule Binding Regulation Of Protein-containing Complex Assembly Microtubule Cytoskeleton Organization Regulation Of Protein Localization To Synapse Regulation Of Cell Cycle Process Regulation Of Microtubule Cytoskeleton Organization Intercellular Canaliculus Regulation Of Protein K48-linked Ubiquitination Cytoskeleton Organization Microtubule-based Process Regulation Of Protein Modification Process Organelle Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Mitotic Nuclear Division Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Nuclear Division Regulation Of Microtubule-based Process Cellular Component Assembly Mitotic Cell Cycle Phase Transition	Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Netrin Receptor Binding Lewy Body Core Dorsal Root Ganglion Development Netrin-activated Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Ganglion Development Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Peptide Binding Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting To Mitochondrion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
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