TUBB3 and SLC7A5

		TUBB3	SLC7A5
Description		tubulin beta 3 class III	solute carrier family 7 member 5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Lamellipodium Filopodium Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body Intercellular Bridge Extracellular Exosome Cell Periphery Mitotic Spindle	Lysosome Lysosomal Membrane Cytosol Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Microvillus Membrane Extracellular Exosome External Side Of Apical Plasma Membrane Amino Acid Transport Complex
	Molecular Function	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Peptide Binding Metal Ion Binding Netrin Receptor Binding	Protein Binding Amino Acid Transmembrane Transporter Activity Aromatic Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity L-tryptophan Transmembrane Transporter Activity Antiporter Activity Thyroid Hormone Transmembrane Transporter Activity Transmembrane Transporter Activity Peptide Antigen Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Axon Guidance Neuron Differentiation Netrin-activated Signaling Pathway Dorsal Root Ganglion Development	Positive Regulation Of Cytokine Production Involved In Immune Response Amino Acid Transmembrane Transport Amino Acid Transport Negative Regulation Of Autophagy Negative Regulation Of Gene Expression Response To Muscle Activity Neutral Amino Acid Transport L-amino Acid Transport Isoleucine Transport L-leucine Transport Methionine Transport Phenylalanine Transport Proline Transport Tryptophan Transport Tyrosine Transport Valine Transport Alanine Transport Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-4 Production Cellular Response To Glucose Starvation Xenobiotic Transport Transmembrane Transport Response To Hyperoxia Positive Regulation Of Glial Cell Proliferation Thyroid Hormone Transport Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Amino Acid Import Across Plasma Membrane Liver Regeneration Transport Across Blood-brain Barrier L-histidine Transport L-alpha-amino Acid Transmembrane Transport Cellular Response To L-arginine L-leucine Import Across Plasma Membrane L-tryptophan Transmembrane Transport Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of L-leucine Import Across Plasma Membrane
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Basigin interactions Amino acid transport across the plasma membrane Tryptophan catabolism
Drugs		Epothilone D Patupilone Ixabepilone CYT997 ZEN-012 Phenethyl Isothiocyanate
Diseases		Congenital fibrosis of the extraocular muscles (CFEOM)
GWAS		Brain morphology (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Squamous cell carcinoma ( 31174203)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum metabolite levels ( 33031748)
Interacting Genes		38 interacting genes: ABCC2 ANXA7 ARHGEF7 CAMSAP3 CDC42 CDKN1A DDX39B DUX4 EEF1G GABARAP GZMK HEXD INSM1 KHDRBS1 LAPTM4A LIG1 LINC01554 MAP7D3 MAPT MRPL28 MTCL1 MTDH OGT PHIP PLK1 RCC1 RILPL2 ROBO1 RSPH1 SCGN SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE WEE2-AS1	1 interacting genes: SLC3A2
Entrez ID		10381	8140
HPRD ID		04044	02552
Ensembl ID		ENSG00000258947	ENSG00000103257
Uniprot IDs		Q13509 Q53G92	Q01650
PDB IDs		5IJ0 5IJ9 5JCO 6E7B 6S8L 6WSL 7LXB 7M18 7M20 7PJF 7SJ7 7SJ8 7SJ9 7SJA 7Z6S 8VRJ 8VRK 8VT7	6IRS 6IRT 6JMQ 7DSK 7DSL 7DSN 7DSQ 8IDA 8J8L 8J8M 8KDD 8KDF 8KDG 8KDH 8KDI 8KDJ 8KDN 8KDO 8KDP 8X0W 8XPU
Enriched GO Terms of Interacting Partners?		Microtubule Binding Regulation Of Protein-containing Complex Assembly Microtubule Cytoskeleton Organization Regulation Of Protein Localization To Synapse Regulation Of Cell Cycle Process Regulation Of Microtubule Cytoskeleton Organization Intercellular Canaliculus Regulation Of Protein K48-linked Ubiquitination Cytoskeleton Organization Microtubule-based Process Regulation Of Protein Modification Process Organelle Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Mitotic Nuclear Division Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Nuclear Division Regulation Of Microtubule-based Process Cellular Component Assembly Mitotic Cell Cycle Phase Transition	Apical Pole Of Neuron Isoleucine Transport L-histidine Transport Exogenous Protein Binding Methionine Transport L-leucine Transmembrane Transporter Activity L-leucine Import Across Plasma Membrane Phenylalanine Transport Amino Acid Transport Complex L-alanine Transmembrane Transport Neuronal Cell Body Aromatic Amino Acid Transmembrane Transporter Activity Valine Transport Tryptophan Transport L-alanine Import Across Plasma Membrane Tyrosine Transport Netrin Receptor Binding Dorsal Root Ganglion Development L-alanine Transmembrane Transporter Activity L-alanine Transport L-leucine Transport Proline Transport Netrin-activated Signaling Pathway Aromatic Amino Acid Transport Branched-chain Amino Acid Transport Thyroid Hormone Transport Alanine Transport Sulfur Amino Acid Transport Ganglion Development Neutral L-amino Acid Transmembrane Transporter Activity Basic Amino Acid Transport Peptide Binding Amino Acid Import Across Plasma Membrane Response To Exogenous DsRNA Neutral Amino Acid Transport Response To DsRNA L-alpha-amino Acid Transmembrane Transport Basal Plasma Membrane L-amino Acid Transport Double-stranded RNA Binding Organic Cation Transport Amino Acid Transmembrane Transport Virus Receptor Activity Filopodium Intercellular Bridge Cell Periphery Hormone Transport Melanosome Structural Constituent Of Cytoskeleton Amino Acid Transport
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