TUBA1B and CCT2

Number of citations of the paper that reports this interaction (PMID 23190606)
1

Data Source:
BioGRID (pull down)

		TUBA1B	CCT2
Gene Name		tubulin, alpha 1b	chaperonin containing TCP1, subunit 2 (beta)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Microtubule Cytoplasmic Microtubule Extracellular Vesicular Exosome	Zona Pellucida Receptor Complex Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Vesicular Exosome
	Molecular Function	Double-stranded RNA Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Ubiquitin Protein Ligase Binding	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Unfolded Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Protein Folding Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Cell Division Cellular Response To Interleukin-4	Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Chaperone-mediated Protein Complex Assembly Toxin Transport
Pathways		Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System	Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs		Epothilone D Epothilone B 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		27 interactors: A2M AGTRAP CCT2 EPN2 ESR1 FYN GRM7 GZMM HDAC6 MAPT MINK1 MTCL1 MYC NFKBIA PFDN5 PIK3R1 PSEN1 PTP4A1 PXN SIAH1 SLX1B SMAD2 SNAP91 TERT TMEM253 TOM1L1 TUBG1	18 interactors: ACTA1 ACTB EEF2 ERLIN2 FCHSD2 HSP90AB1 HSP90B1 PRPF40A PSMC6 PSMD2 RPS3 SSSCA1 SUMO4 TUBA1B TUBB VAV2 VRK2 YWHAG
Entrez ID		10376	10576
HPRD ID		03960	06895
Ensembl ID		ENSG00000123416	ENSG00000166226
Uniprot IDs		P68363	P78371
PDB IDs		2E4H
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Response To Growth Factor T Cell Receptor Signaling Pathway Negative Regulation Of Signal Transduction Antigen Receptor-mediated Signaling Pathway Regulation Of Catalytic Activity Response To Stress Regulation Of Cell Death Negative Regulation Of Signaling Cellular Protein Complex Assembly Cellular Response To Growth Factor Stimulus Cell Communication Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Stimulus Cellular Response To Stimulus Response To DsRNA Programmed Cell Death Regulation Of Metabolic Process Tube Morphogenesis Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Cell Death Death Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Regulation Of Microtubule-based Movement Regulation Of Cell Morphogenesis Developmental Process Cellular Response To Stress Regulation Of Cell Differentiation Signaling Vascular Endothelial Growth Factor Receptor Signaling Pathway Transport Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Organelle Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Receptor Activity Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Signal Transduction Negative Regulation Of Programmed Cell Death Growth Hormone Receptor Signaling Pathway	Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Division Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cellular Protein Metabolic Process Cell Cycle Phase Transition Positive Regulation Of Transferase Activity Regulation Of Apoptotic Process Protein Folding Immune System Process Regulation Of Cell Death Cell Cycle Process Endocytosis Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Innate Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Response To Stress Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Immune Response-regulating Signaling Pathway Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interleukin-4 Modification-dependent Protein Catabolic Process Movement Of Cell Or Subcellular Component Cellular Response To Stress Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Catalytic Activity Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Programmed Cell Death Response To Interleukin-4 Cellular Protein Catabolic Process Cell Death Death Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Catalytic Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of DNA N-glycosylase Activity Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint 'de Novo' Posttranslational Protein Folding Protein Catabolic Process Phagocytosis
Tagcloud ?		accounts annotation aurora bad bub1 cdc2 cdc25 cebpb cgh compact correlating delineated e2f1 exceptions explorative exploratory gepat hallmark hodgkin implicates incurable mantle mcl proliferative refine socs1 tight wee1 wilcoxon	antral atresia atretic bga build categorized cattle cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis tgm2 transcriptomic ultimately
Tagcloud (Difference) ?		accounts annotation aurora bad bub1 cdc2 cdc25 cebpb cgh compact correlating delineated exceptions explorative exploratory gepat hallmark hodgkin implicates incurable mantle mcl proliferative refine socs1 tight wee1 wilcoxon	antral atresia atretic bga build categorized cattle cyp11a1 cyp19a1 dab2 dairy dsg2 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis tgm2 transcriptomic ultimately
Tagcloud (Intersection) ?		e2f1