SH3RF2

Description		SH3 domain containing ring finger 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Zinc Ion Binding Transferase Activity Phosphatase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Ubiquitination Positive Regulation Of Cell Migration Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autoubiquitination
Pathways
Drugs
Diseases
GWAS		Bacteremia ( 27236921) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261)
Interacting Genes		23 interacting genes: AKAP8L AMOTL2 APP ATXN7L2 BAG4 BANP CBY2 CCDC102B CYSRT1 EFS FASLG GOLGA2 HOMEZ LMNA LZTS2 MTUS2 NEK6 PAK4 PPP1CA PPP1CC RBPMS UBE2N VPS37C
Entrez ID		153769
HPRD ID		10229
Ensembl ID		ENSG00000156463
Uniprot IDs		Q08AM8 Q8TEC5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway PTW/PP1 Phosphatase Complex Response To Lead Ion Transition Metal Ion Binding Cell Division Nuclear Speck Cadherin Binding Involved In Cell-cell Adhesion Lamin Binding Membrane Disassembly Nuclear Membrane Disassembly Protein Serine/threonine Kinase Binding Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock
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