- and ZMYM5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		-	ZMYM5
Description		cystathionine beta-synthase like	zinc finger MYM-type containing 5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus
	Molecular Function	Catalytic Activity Cystathionine Beta-synthase Activity Protein Binding Lyase Activity Oxygen Binding Enzyme Binding Heme Binding Pyridoxal Phosphate Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Nitrite Reductase (NO-forming) Activity Carbon Monoxide Binding Nitric Oxide Binding Modified Amino Acid Binding S-adenosyl-L-methionine Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Endochondral Ossification Blood Vessel Remodeling Cysteine Metabolic Process Cysteine Biosynthetic Process From Serine L-serine Metabolic Process L-serine Catabolic Process Superoxide Metabolic Process Amino Acid Biosynthetic Process Serine Family Amino Acid Metabolic Process Regulation Of Nitric Oxide Mediated Signal Transduction Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration L-cysteine Catabolic Process Cerebellum Morphogenesis Response To Nutrient Levels DNA Protection Negative Regulation Of Apoptotic Process Homocysteine Catabolic Process Sulfur Compound Biosynthetic Process Regulation Of JNK Cascade Homocysteine Metabolic Process Response To Folic Acid Maternal Process Involved In Female Pregnancy Cartilage Development Involved In Endochondral Bone Morphogenesis Hydrogen Sulfide Biosynthetic Process Cellular Response To Hypoxia Blood Vessel Diameter Maintenance	Negative Regulation Of Transcription By RNA Polymerase II
Pathways		Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs		Pyridoxal phosphate Ademetionine Serine Cysteine
Diseases
GWAS		HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)	Alcohol use disorder (consumption score) ( 30940813) Arterial stiffness (brachial-ankle pulse wave velocity) ( 32790701) Methadone dose in opioid dependence ( 28115739)
Interacting Genes		4 interacting genes: OGT PIAS2 UBE2I ZMYM5	33 interacting genes: - APP CAMK2B CARD9 CBS CREBBP DAPK1 DES FADD FBXO7 FTCD GTF2IRD1 HMBOX1 HOMER1 ITSN1 LCE3B LRRK2 MFHAS1 MORC3 PAX5 PDE9A PRMT1 SKIL SNIP1 SUMO1 SUMO2 TFG TRAF2 TRAF4 TRIP13 UBQLN1 ZBTB26 ZNRD2
Entrez ID		102724560	9205
HPRD ID			10324
Ensembl ID		ENSG00000274276	ENSG00000132950
Uniprot IDs		P35520	Q9UJ78
PDB IDs		1JBQ 1M54 4COO 4L0D 4L27 4L28 4L3V 4PCU 4UUU 5MMS 7QGT 8S5H 8S5I 8S5J 8S5K 8S5L 8S5M 8STW	2DAS
Enriched GO Terms of Interacting Partners?		SUMO Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Protein Sumoylation Negative Regulation Of RNA Biosynthetic Process SUMO Conjugating Enzyme Activity PML Body Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Protein O-acetylglucosaminyltransferase Activity SUMO Ligase Complex HLH Domain Binding Regulation Of DNA-templated Transcription Small Protein Activating Enzyme Binding Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of RNA Metabolic Process Carbon Catabolite Regulation Of Transcription Regulation Of Transcription By Glucose Mitotic Nuclear Membrane Reassembly Regulation Of Nucleobase-containing Compound Metabolic Process NSL Complex Transferase Complex SUMO Ligase Activity Protein Modification Process Transferase Activity Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Acetylglucosaminyltransferase Activity Transcription Factor Binding Regulation Of Intracellular Signal Transduction Nuclear Membrane Reassembly Regulation Of Gene Expression Synaptonemal Complex Histone Acetyltransferase Complex Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance SMAD Protein Signal Transduction Regulation Of Macromolecule Biosynthetic Process	Identical Protein Binding Regulation Of JNK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signaling Adaptor Activity Positive Regulation Of Protein Metabolic Process PML Body Positive Regulation Of Proteolysis Regulation Of MAPK Cascade Response To Stress Cysteine Biosynthetic Process From Serine Cystathionine Beta-synthase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Protein-containing Complex Organization Regulation Of Apoptotic Process Regulation Of Postsynapse Organization Cytosol Regulation Of Apoptotic Signaling Pathway S-adenosyl-L-methionine Binding Enzyme Binding Regulation Of Programmed Cell Death Cysteine Biosynthetic Process Via Cystathionine Carbon Monoxide Binding Protein-containing Complex Assembly Positive Regulation Of MAPK Cascade Cysteine Biosynthetic Process Homocysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process Cellular Response To Stress Presynaptic Cytosol Positive Regulation Of Signal Transduction Postsynaptic Cytosol Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Multicellular Organismal Process L-serine Catabolic Process Transsulfuration Nitrite Reductase (NO-forming) Activity Cerebellum Morphogenesis Hydrogen Sulfide Metabolic Process L-cysteine Catabolic Process Nitric Oxide Binding Tumor Necrosis Factor Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade
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