RCAN2 and PPP3CA

Number of citations of the paper that reports this interaction (PMID 10861295)
100

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RCAN2	PPP3CA
Gene Name		regulator of calcineurin 2	protein phosphatase 3, catalytic subunit, alpha isozyme
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcineurin Complex Z Disc Sarcolemma
	Molecular Function	Nucleotide Binding	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Response To Oxidative Stress Short-term Memory Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Transition Between Fast And Slow Fiber Dephosphorylation Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Regulation Of Synaptic Transmission Positive Regulation Of NFAT Protein Import Into Nucleus Response To Calcium Ion Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To Glucose Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways			Signaling by GPCR Ca2+ pathway Opioid Signalling DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Blood pressure ( 22763476) Corneal structure ( 21979947)
Protein-Protein Interactions		2 interactors: PPP3CA TCEB1	24 interactors: AKAP5 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 KCNIP3 MARCH7 MYOZ2 MYOZ3 PPP3R1 PRKCZ RCAN1 RCAN2 SOD1 SYNJ1
Entrez ID		10231	5530
HPRD ID		05342	00234
Ensembl ID		ENSG00000172348	ENSG00000138814
Uniprot IDs		B2R612 Q14206	Q08209
PDB IDs			1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z
Enriched GO Terms of Interacting Partners?		Transition Between Fast And Slow Fiber Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Calcineurin-NFAT Signaling Cascade Regulation Of Skeletal Muscle Adaptation Positive Regulation Of NFAT Protein Import Into Nucleus Inositol Phosphate-mediated Signaling Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Skeletal Muscle Fiber Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Myotube Cell Development Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of DNA-templated Transcription, Elongation Response To Amphetamine Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Peptide Secretion Positive Regulation Of Viral Transcription Muscle Fiber Development Response To Amine Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Drug Regulation Of DNA-templated Transcription In Response To Stress Myotube Differentiation Cellular Response To Glucose Stimulus Negative Regulation Of Hormone Secretion Transcription Elongation From RNA Polymerase II Promoter Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Viral Transcription Positive Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Glucose Homeostasis Regulation Of Postsynaptic Membrane Potential Cellular Response To Carbohydrate Stimulus DNA-templated Transcription, Elongation Multicellular Organismal Response To Stress Regulation Of Transcription Factor Import Into Nucleus Calcium-mediated Signaling Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Secretion Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels	Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signaling Cell Communication Behavior Cellular Response To Histamine Synaptic Transmission, GABAergic Response To Organic Cyclic Compound Calcineurin-NFAT Signaling Cascade Response To Histamine Single-organism Behavior Regulation Of Neuron Death Cellular Response To Stimulus Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Signal Transduction Inositol Phosphate-mediated Signaling Cellular Response To Ammonium Ion Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Gamma-aminobutyric Acid Signaling Pathway Regulation Of Cell Activation Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Neurological System Process Positive Regulation Of Cellular Metabolic Process Regulation Of T Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Stimulus Synaptic Transmission Negative Regulation Of Apoptotic Process Cell-cell Signaling Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Transport Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Death
Tagcloud ?		acd acd1 acd21 acd6 acds analysing bidirectional bioinformatic calcineurin clic collocate duplication eukarya evolved fibre invertebrates nat nfatc rcan3 remodelling rounds runx scenario segmental timely transposable unmethylated vertebrates	adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Difference) ?		acd acd1 acd21 acd6 acds analysing bidirectional bioinformatic calcineurin clic collocate duplication eukarya evolved fibre invertebrates nat nfatc rcan3 remodelling rounds runx scenario segmental timely transposable unmethylated vertebrates	adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Intersection) ?