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PSMD14 and TXNL1
Number of citations of the paper that reports this interaction (PMID
19781552
)
18
Data Source:
BioGRID
(affinity chromatography technology, pull down)
PSMD14
TXNL1
Gene Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
thioredoxin-like 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Lid Subcomplex
Proteasome Accessory Complex
Extracellular Vesicular Exosome
Proteasome Complex
Nucleus
Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
Metallopeptidase Activity
Metal Ion Binding
Endopeptidase Activator Activity
Proteasome Binding
Protein Disulfide Oxidoreductase Activity
Disulfide Oxidoreductase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Double-strand Break Repair Via Homologous Recombination
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Double-strand Break Repair Via Nonhomologous End Joining
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Positive Regulation Of Endopeptidase Activity
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Proteasomal Protein Catabolic Process
Protein K63-linked Deubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Glycerol Ether Metabolic Process
Cell Redox Homeostasis
Oxidation-reduction Process
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions
8 interactors:
ADRM1
DPY30
FAM9B
MEOX2
MITF
OLIG1
PSMD7
TXNL1
4 interactors:
PSMC3
PSMD14
SH3BP4
SUMO4
Entrez ID
10213
9352
HPRD ID
06208
04335
Ensembl ID
ENSG00000115233
Uniprot IDs
O00487
O43396
PDB IDs
1GH2
1WWY
Enriched GO Terms of Interacting Partners
?
Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
RNA Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Somite Specification
Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process
Proteasome Assembly
Cell Fate Commitment
Positive Regulation Of Proteolysis
Positive Regulation Of Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Regulation Of Metabolic Process
Segment Specification
Regulation Of Nitrogen Compound Metabolic Process
Glycerol Ether Metabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Transferase Activity
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Ligase Activity
DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein Modification By Small Protein Conjugation
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Signal Transduction In Response To DNA Damage
Mitotic DNA Damage Checkpoint
Regulation Of Cell Cycle Arrest
Mitotic DNA Integrity Checkpoint
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Protein Ubiquitination
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Signal Transduction By P53 Class Mediator
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Negative Regulation Of Catalytic Activity
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Ubiquitination
Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cellular Protein Catabolic Process
DNA Damage Checkpoint
Positive Regulation Of Wnt Signaling Pathway
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Checkpoint
Protein Polyubiquitination
Negative Regulation Of Signal Transduction
Negative Regulation Of Wnt Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Signaling
Positive Regulation Of Protein Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Tagcloud
?
100nm
24h
26s
4t1
avenues
bortezomib
card10
controversial
dffb
entirely
folding
grp78
ingenuity
ipa
label
lc
modulated
myeloma
noxa
nucleic
proteasomal
proteasome
proteolytic
puma
sequestosome
tceb2
top
traf3
trp53bp2
Tagcloud (Difference)
?
100nm
24h
26s
4t1
avenues
bortezomib
card10
controversial
dffb
entirely
folding
grp78
ingenuity
ipa
label
lc
modulated
myeloma
noxa
nucleic
proteasomal
proteasome
proteolytic
puma
sequestosome
tceb2
top
traf3
trp53bp2
Tagcloud (Intersection)
?