NME6 and ATP5PO

Number of citations: 72 (PubMedID 27107012)
Data Source: BioGRID (two hybrid)

		NME6	ATP5PO
Name		NME/NM23 nucleoside diphosphate kinase 6	ATP synthase peripheral stalk subunit OSCP
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Nucleus Mitochondrion Mitochondrial Inner Membrane Plasma Membrane Cell Surface Membrane Proton-transporting ATP Synthase Complex
	Molecular Function	Nucleotide Binding Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding	Protein Binding ATP Hydrolysis Activity Protein-containing Complex Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Estradiol Binding
	Biological Process	GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Apoptotic Process Nucleotide Metabolic Process Pyrimidine Ribonucleotide Salvage Negative Regulation Of Cell Growth Negative Regulation Of Mitotic Nuclear Division	ATP Biosynthetic Process Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Cellular Response To CAMP Cellular Response To Cytokine Stimulus Proton Transmembrane Transport
Pathways		None	Formation of ATP by chemiosmotic coupling Cristae formation Mitochondrial protein degradation
Drugs		None	Artenimol
GWAS		Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	No GWAS studies recorded
Novel Interactors		None recorded	2 novel interactors: CBR3 RCAN1
Interacting Genes		3 interacting genes: APP ATP5PO ZNRD2	19 interacting genes: APP CCDC136 CEP70 ERCC6 GOLGA2 HMBOX1 KRT13 KRT15 MIPOL1 NDC80 NME6 NT5C2 PNMA1 TEX13A TFIP11 TRIP6 USHBP1 ZBTB14 ZNF76
Entrez ID		10201	539
HPRD ID		09219	02899
Ensembl ID		ENSG00000172113	ENSG00000241837
Uniprot IDs		A0A0C4DG91 A0A2R8Y7V2 C9JQB1 O75414	P48047
PDB IDs		Not available	8H9E 8H9I 8H9L 8H9P 8H9S 8H9T 8H9U 8H9V 8KI3
GO Terms Enriched among Interactors		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Response To CAMP Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Purine-containing Compound Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Estradiol Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining