DNAL4 and UBA7

		DNAL4	UBA7
Description		dynein axonemal light chain 4	ubiquitin like modifier activating enzyme 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Cilium Dynein Complex Cell Projection	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Microtubule Motor Activity Protein Binding Identical Protein Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity ISG15 Activating Enzyme Activity
	Biological Process	Microtubule-based Process Microtubule-based Movement	DNA Damage Response Protein Ubiquitination Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Innate Immune Response
Pathways		Retrograde neurotrophin signalling	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS			Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Menarche (age at onset) ( 25231870) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 21297633) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		14 interacting genes: CHIC2 DYNLL2 FHL5 GNA14 GPBP1 KRTAP10-3 KRTAP12-3 KRTAP9-8 NFATC2IP NOTCH2NLA NTAQ1 NUDT22 SCTR TRIM54	7 interacting genes: FAS ISG15 LCOR RSPH1 UBE2E1 UBE2L3 UBE2L6
Entrez ID		10126	7318
HPRD ID		13239	01873
Ensembl ID		ENSG00000100246	ENSG00000182179
Uniprot IDs		O96015	P41226
PDB IDs			8OIF 8SE9 8SEA 8SEB 8SV8 8WWX
Enriched GO Terms of Interacting Partners?			ISG15-protein Conjugation Ubiquitin Conjugating Enzyme Activity ISG15 Transferase Activity Ubiquitin-like Protein Transferase Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Polyubiquitination Post-translational Protein Modification Macromolecule Catabolic Process Fas Signaling Pathway Ubiquitin Ligase Complex Proteolysis Radial Spoke Head 1 Radial Spoke Head 3 Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Oligomerization Cellular Response To Hyperoxia Radial Spoke Head CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Activation-induced Cell Death Of T Cells Outer Dense Fiber Regulation Of Protein Ubiquitination Necroptotic Signaling Pathway Protein Modification Process Ubiquitin-protein Transferase Activator Activity
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