PREB and RAB10

Data Source: HiPPIP (Novel)

		PREB	RAB10
Name		prolactin regulatory element binding	RAB10, member RAS oncogene family
Structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Exit Site	Golgi Membrane Exocyst Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cilium Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Insulin-responsive Compartment Cell Projection Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Exocytic Vesicle Endoplasmic Reticulum Tubular Network Secretory Vesicle
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Myosin V Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Regulation Of COPII Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Lipoprotein Transport COPII Vesicle Coating COPII-coated Vesicle Cargo Loading	Exocytosis Golgi To Plasma Membrane Transport Axonogenesis Protein Transport Vesicle-mediated Transport Endosomal Transport Antigen Processing And Presentation Polarized Epithelial Cell Differentiation Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Regulated Exocytosis Establishment Of Neuroblast Polarity Endoplasmic Reticulum Tubular Network Organization Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Cell-cell Adhesion Protein Localization To Basolateral Plasma Membrane
Pathways		COPII-mediated vesicle transport XBP1(S) activates chaperone genes Cargo concentration in the ER	Translocation of SLC2A4 (GLUT4) to the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
GWAS		Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Apolipoprotein B levels ( 32203549 ) Glycated hemoglobin levels ( 34059833 ) Immune response to smallpox vaccine (IL-6) ( 22542470 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Metabolite levels (HVA) ( 23319000 ) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000 ) Metabolite levels (HVA/MHPG ratio) ( 23319000 ) Platelet distribution width ( 32888494 )
Novel Interactors		1 novel interactors: RAB10	8 novel interactors: ATRAID DNAJC27 EFR3B GPN1 IFT172 PLP2 PREB TP53I3
Interacting Genes		2 interacting genes: SMAD1 TGFBR1	10 interacting genes: APP CEBPA ENOPH1 EVI5L MICAL1 MTNR1A PPBP RABIF RIMS1 SEPTIN9
Entrez ID		10113	10890
HPRD ID		16216	06692
Ensembl ID		ENSG00000138073	ENSG00000084733
Uniprot IDs		B5MC98 Q05DB2 Q9HCU5	P61026
PDB IDs		5TF2	5LPN 5SZJ
GO Terms Enriched among Interactors		I-SMAD Binding Regulation Of Cartilage Development Positive Regulation Of Vasculature Development Mesodermal Cell Fate Commitment Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Homomeric SMAD Protein Complex Osteoblast Fate Commitment Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell Fate Commitment Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Protein Localization To Basolateral Plasma Membrane Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Anatomical Structure Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Cellular Response To Growth Factor Stimulus Regulation Of Vasculature Development Heteromeric SMAD Protein Complex Anti-Mullerian Hormone Receptor Signaling Pathway Response To Growth Factor Ubiquitin Protein Ligase Binding SMAD Protein Complex Positive Regulation Of Cell Projection Organization DEAD/H-box RNA Helicase Binding Positive Regulation Of Mesenchymal Stem Cell Proliferation Myofibroblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Ventricular Compact Myocardium Morphogenesis Parathyroid Gland Development Germ Cell Migration Transforming Growth Factor Beta Receptor Activity Trophoblast Cell Migration Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Activity, Type I Insulin-responsive Compartment Primary MiRNA Binding Coronary Artery Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Secretory Vesicle Pattern Specification Process Type II Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation	None