PREB

Gene Name		prolactin regulatory element binding
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated ER To Golgi Vesicle-mediated Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Transport Protein N-linked Glycosylation Via Asparagine Endoplasmic Reticulum Unfolded Protein Response Post-translational Protein Modification Cellular Protein Metabolic Process COPII Vesicle Coating Membrane Organization
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) XBP1(S) activates chaperone genes Defective MOGS causes MOGS-CDG (CDG-2b) IRE1alpha activates chaperones Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 COPII (Coat Protein 2) Mediated Vesicle Transport Unfolded Protein Response (UPR) ER to Golgi Transport Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: SMAD1 TGFBR1
Entrez ID		10113
HPRD ID		16216
Ensembl ID		ENSG00000138073
Uniprot IDs		Q9HCU5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cartilage Development Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Positive Regulation Of Cell Projection Organization Cell Fate Commitment Kidney Development Renal System Development Urogenital System Development Regulation Of Cell Morphogenesis Pattern Specification Process Regulation Of Cell Projection Organization Primary MiRNA Processing Heart Development Skeletal System Development Osteoblast Fate Commitment Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Parathyroid Gland Development Embryonic Morphogenesis Gamete Generation Negative Regulation Of Cell Proliferation Response To Wounding SMAD Protein Complex Assembly Endothelial Cell Activation Pathway-restricted SMAD Protein Phosphorylation Sexual Reproduction Positive Regulation Of SMAD Protein Import Into Nucleus Multicellular Organismal Reproductive Process Mesodermal Cell Fate Commitment Multicellular Organism Reproduction Regulation Of Cell Development Regulation Of SMAD Protein Import Into Nucleus Cardiovascular System Development Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Germ Cell Migration Negative Regulation Of Programmed Cell Death Cardiac Muscle Cell Proliferation Pharyngeal System Development Negative Regulation Of Cell Death Production Of MiRNAs Involved In Gene Silencing By MiRNA Response To Cholesterol Cellular Response To BMP Stimulus Reproduction Anatomical Structure Formation Involved In Morphogenesis
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