PMM2 and ACY3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PMM2	ACY3
Gene Name		phosphomannomutase 2	aspartoacylase (aminocyclase) 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Neuronal Cell Body Extracellular Vesicular Exosome	Cytosol Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Phosphomannomutase Activity	Molecular_function Aminoacylase Activity Hydrolase Activity, Acting On Ester Bonds Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process GDP-mannose Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Mannose Biosynthetic Process Post-translational Protein Modification Cellular Protein Metabolic Process	Xenobiotic Metabolic Process Biological_process Viral Process Small Molecule Metabolic Process
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Synthesis of GDP-mannose Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins	Aflatoxin activation and detoxification Biological oxidations Metabolic disorders of biological oxidation enzymes Defective ACY1 causes encephalopathy
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: ACY3	14 interactors: AAMDC ASPA GORASP2 KRTAP10-3 KRTAP10-8 LNX1 MAP3K8 NEDD4L NOTCH2NL PIAS2 PLEKHF2 PMM2 RARG RRAS
Entrez ID		5373	91703
HPRD ID		03472	12422
Ensembl ID		ENSG00000140650	ENSG00000132744
Uniprot IDs		F5H0W0 O15305 Q59F02	Q96HD9
PDB IDs		2AMY 2Q4R
Enriched GO Terms of Interacting Partners?		Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus
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