USH1C and CDH23

Number of citations of the paper that reports this interaction (PMID 12485990)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		USH1C	CDH23
Gene Name		Usher syndrome 1C (autosomal recessive, severe)	cadherin-related 23
Image
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Cytoskeleton Plasma Membrane Brush Border Stereocilium Apical Part Of Cell Synapse	Plasma Membrane Membrane Integral Component Of Membrane Stereocilium
	Molecular Function	Protein Binding Spectrin Binding Myosin Tail Binding Actin Filament Binding	Calcium Ion Binding Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Sensory Perception Of Sound Parallel Actin Filament Bundle Assembly Inner Ear Morphogenesis Auditory Receptor Cell Differentiation Photoreceptor Cell Maintenance Sensory Perception Of Light Stimulus Equilibrioception	Calcium Ion Transport Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Visual Perception Sensory Perception Of Sound Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Photoreceptor Cell Maintenance Response To Stimulus Sensory Perception Of Light Stimulus Equilibrioception Cytosolic Calcium Ion Homeostasis
Pathways
Drugs
Diseases
GWAS			Vitiligo ( 22951725)
Protein-Protein Interactions		9 interactors: ANKS4B CDH23 CTNNAL1 MIPOL1 MYO7A QKI RAC1 USH1G USHBP1	2 interactors: MYO7A USH1C
Entrez ID		10083	64072
HPRD ID		09241	05699
Ensembl ID		ENSG00000006611	ENSG00000107736
Uniprot IDs		Q9Y6N9	A5D6V9 Q6P152 Q8N5B3 Q9H251
PDB IDs		1X5N 2KBQ 2KBR 2KBS 2LSR 3K1R	2KBR 2KBS 2LSR
Enriched GO Terms of Interacting Partners?		Equilibrioception Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation Neuromuscular Process Controlling Balance Inner Ear Morphogenesis Ear Morphogenesis Auditory Receptor Cell Morphogenesis Neuromuscular Process Sensory Perception Of Sound Auditory Receptor Cell Development Sensory Perception Of Light Stimulus Tissue Homeostasis Sensory Perception Of Mechanical Stimulus Inner Ear Development Ear Development Multicellular Organismal Homeostasis Auditory Receptor Cell Differentiation Photoreceptor Cell Maintenance Hair Cell Differentiation Inner Ear Receptor Cell Development Embryonic Organ Morphogenesis Retina Homeostasis Embryonic Organ Development Sensory Organ Development Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production 3'-UTR-mediated MRNA Destabilization Embryonic Morphogenesis Epidermal Cell Differentiation Engulfment Of Apoptotic Cell Visual Perception Mast Cell Chemotaxis Sensory Perception Epithelial Cell Development MRNA Destabilization Tangential Migration From The Subventricular Zone To The Olfactory Bulb Organ Morphogenesis Nervous System Development Post-embryonic Organ Morphogenesis Phagocytosis Epidermis Development Olfactory Bulb Interneuron Development Auditory Receptor Cell Stereocilium Organization Anatomical Structure Morphogenesis Regulation Of Hydrogen Peroxide Metabolic Process RNA Destabilization Neuron Differentiation Embryo Development Regulation Of Respiratory Burst Neurological System Process	Equilibrioception Auditory Receptor Cell Differentiation Hair Cell Differentiation Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation Neuromuscular Process Controlling Balance Inner Ear Morphogenesis Ear Morphogenesis Neuromuscular Process Epidermal Cell Differentiation Sensory Perception Of Sound Sensory Perception Of Light Stimulus Sensory Perception Of Mechanical Stimulus Inner Ear Development Ear Development Epidermis Development Parallel Actin Filament Bundle Assembly Embryonic Organ Morphogenesis Embryonic Organ Development Epithelial Cell Differentiation Sensory Organ Development Post-embryonic Organ Morphogenesis Auditory Receptor Cell Stereocilium Organization Embryonic Morphogenesis Actin Filament-based Process Auditory Receptor Cell Morphogenesis Phagolysosome Assembly Sensory Perception Auditory Receptor Cell Development Inner Ear Receptor Stereocilium Organization Organ Morphogenesis Epithelium Development Neuron Differentiation Embryo Development Neurological System Process Photoreceptor Cell Maintenance Pigment Granule Transport Eye Photoreceptor Cell Development Inner Ear Receptor Cell Development Phagosome Maturation Photoreceptor Cell Development Eye Photoreceptor Cell Differentiation Generation Of Neurons Lysosome Organization Neurogenesis Retina Homeostasis Cellular Pigmentation Actin Filament-based Movement Tissue Development Actin Filament Bundle Assembly
Tagcloud ?			alters annotation ca3 candidate dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Difference) ?			alters annotation ca3 candidate dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Intersection) ?