PWP2 and DCAF7

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		PWP2	DCAF7
Description		PWP2 small subunit processome component	DDB1 and CUL4 associated factor 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Nuclear Body Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	RNA Binding Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Ribosomal Small Subunit Assembly Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Ribosomal Small Subunit Biogenesis	Protein Ubiquitination
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Association of TriC/CCT with target proteins during biosynthesis Neddylation
Drugs
Diseases
GWAS			Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: CFTR DCAF7 MAPT MTDH TOM1L1	7 interacting genes: APP ATP13A2 BMPR1B DYRK1B LIG1 PWP2 YWHAG
Entrez ID		5822	10238
HPRD ID		03279	09340
Ensembl ID		ENSG00000241945	ENSG00000136485
Uniprot IDs		Q15269	P61962
PDB IDs		7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Protein-folding Chaperone Binding Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Histone-dependent DNA Binding Phosphatidylinositol Binding Tubulin Complex Neurofibrillary Tangle Assembly Microtubule Lateral Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Main Axon Regulation Of Tubulin Deacetylation Protein-macromolecule Adaptor Activity Negative Regulation Of Mitochondrial Fission Negative Regulation Of Tubulin Deacetylation Intracellular Distribution Of Mitochondria Neurofibrillary Tangle Positive Regulation Of Protein Localization To Synapse Plus-end-directed Organelle Transport Along Microtubule Positive Regulation Of Protein Autophosphorylation Intercellular Canaliculus Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Lipoprotein Particle Binding Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Amelogenesis Cellular Response To Brain-derived Neurotrophic Factor Stimulus Inclusion Body Assembly Minor Groove Of Adenine-thymine-rich DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Protein Deacetylation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Endosome Membrane Phosphatidylinositol Bisphosphate Binding Negative Regulation Of Membrane Potential Axolemma Negative Regulation Of Mitochondrial Membrane Potential Regulation Of Protein Autophosphorylation Cytoplasm Cellular Response To Forskolin	Cellular Response To Manganese Ion Response To Manganese Ion Cellular Response To Stress
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