MEF2B and CABIN1

Number of citations of the paper that reports this interaction (PubMedID 12700764)
0

Data Source:
HPRD (in vitro)

		MEF2B	CABIN1
Description		myocyte enhancer factor 2B	calcineurin binding protein 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Cell Junction	Nucleus Nucleoplasm Cytosol Aggresome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Phosphatase Inhibitor Activity Protein Binding Nucleosome Binding
	Biological Process	Heart Development Muscle Organ Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development	Chromatin Organization Nucleosome Assembly Cell Surface Receptor Signaling Pathway
Pathways		Myogenesis	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Diastolic blood pressure ( 29403010 30487518) Mean arterial pressure ( 29403010 30487518) Multiple sclerosis ( 31604244) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Systolic blood pressure ( 30487518)	Acne (severe) ( 24927181) Amyotrophic lateral sclerosis ( 23624525) Coronary artery disease ( 29212778) Femur bone mineral density x serum urate levels interaction ( 34046847) Monocyte count ( 32888494) S-phenylmercapturic acid levels in smokers ( 26959369) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		2 interacting genes: CABIN1 HDAC4	13 interacting genes: AMPH BORCS8-MEF2B CALM1 CAMK4 DNM1 GRM1 LCOR MEF2B MEF2D PPP3CA PPP3CB PPP3CC YWHAQ
Entrez ID		100271849	23523
HPRD ID		19467	10369
Ensembl ID		ENSG00000213999	ENSG00000099991
Uniprot IDs		Q02080	A0A087WWW8 Q9Y6J0
PDB IDs		1N6J 1TQE 6BYY 6BZ1 6C9L 6WC2 6WC5	1N6J
Enriched GO Terms of Interacting Partners?		Response To Muscle Inactivity Response To Denervation Involved In Regulation Of Muscle Adaptation Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Macromolecule Deacylation Negative Regulation Of Transcription By Competitive Promoter Binding Potassium Ion Binding Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Sumoylation Negative Regulation Of Glycolytic Process Chromatin Remodeling Cardiac Muscle Hypertrophy Protein Deacetylation SUMO Transferase Activity Muscle Hypertrophy Protein Lysine Deacetylase Activity Response To Inactivity DNA-binding Transcription Activator Activity Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of ATP Metabolic Process Chromatin Organization Positive Regulation Of Protein Sumoylation Aggresome Nucleosome Binding Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Protein Phosphatase Inhibitor Activity Regulation Of Myotube Differentiation Type I Interferon-mediated Signaling Pathway Regulation Of Glycolytic Process Protein Sumoylation Regulation Of Carbohydrate Catabolic Process Transcription Repressor Complex Interferon-mediated Signaling Pathway Negative Regulation Of Muscle Cell Differentiation Regulation Of ATP Metabolic Process Response To Interleukin-1 Regulation Of Purine Nucleotide Metabolic Process Regulation Of Striated Muscle Cell Differentiation B Cell Differentiation Negative Regulation Of Small Molecule Metabolic Process Cell Surface Receptor Signaling Pathway Nucleosome Assembly Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding Regulation Of Generation Of Precursor Metabolites And Energy Nucleosome Organization	Negative Regulation Of Monoatomic Ion Transmembrane Transport Calcineurin-mediated Signaling Calmodulin-dependent Protein Phosphatase Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Protein Serine/threonine Phosphatase Complex Histone Deacetylase Binding Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Protein Dimerization Activity Negative Regulation Of Cation Transmembrane Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-NFAT Signaling Cascade Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Import Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Import Calcium-mediated Signaling Positive Regulation Of Calcium-mediated Signaling Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Calmodulin Binding Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transport Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Regulation Of Monoatomic Cation Transmembrane Transport Heart Development Positive Regulation Of Calcium Ion Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Muscle Organ Development Regulation Of Metal Ion Transport Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Dephosphorylation Cardiac Muscle Hypertrophy Regulation Of Synaptic Vesicle Endocytosis Phosphoprotein Phosphatase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Muscle Structure Development
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