PACS1 and AOPEP

		PACS1	AOPEP
Description		phosphofurin acidic cluster sorting protein 1	aminopeptidase O (putative)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol COPI-coated Vesicle	Nucleus Nucleolus Cytoplasm
	Molecular Function	Protein Binding Transmembrane Transporter Binding	Aminopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Lymphocyte Homeostasis Protein Localization To Golgi Apparatus Protein Localization To Plasma Membrane	Proteolysis
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 21926972 31043756 33263727 34002096) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Electroencephalogram traits ( 25387704) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Obesity (early onset extreme) ( 23563609) Serum uric acid levels ( 32514006) Waist circumference adjusted for body mass index ( 34021172)	Hodgkin's lymphoma ( 34216518)
Interacting Genes		10 interacting genes: CLCN7 CSNK2A1 FURIN GGA3 IGF2R JUN PKD2 PPP2CA PPP2CB VAMP4	9 interacting genes: BMPR1A BUB1 CDH1 CDKN2A DLC1 EGFR MLH3 NRAS SMAD4
Entrez ID		55690	84909
HPRD ID		06320	07476
Ensembl ID		ENSG00000175115	ENSG00000148120
Uniprot IDs		Q6VY07	Q8N6M6
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Metal Ion Golgi To Plasma Membrane Transport Trans-Golgi Network Post-Golgi Vesicle-mediated Transport Trans-Golgi Network Transport Vesicle Liver Development Transforming Growth Factor Beta Receptor Signaling Pathway FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Response To Lead Ion Negative Regulation Of DNA Repair Vacuolar Transport Negative Regulation Of Double-strand Break Repair Vesicle-mediated Transport To The Plasma Membrane Response To Calcium Ion Host-mediated Activation Of Viral Process Phosphoprotein Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Transmembrane Transporter Binding Cellular Response To Fluid Shear Stress Metanephric Cortical Collecting Duct Development Response To Fluid Shear Stress Metanephric Cortex Development Metanephric Distal Tubule Development RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Golgi To Plasma Membrane Protein Transport Homocarnosine Synthase Activity Carnosine Synthase Activity Carnosine Biosynthetic Process Kinesin I Complex Tau Protein Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Chloride:proton Antiporter Activity Lysosome Positive Regulation Of Protein Catabolic Process Protein Targeting To Vacuole Rab GDP-dissociation Inhibitor Activity Leading Edge Cell Differentiation Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Peptidase Activity Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Polycystin Complex Metanephric Smooth Muscle Tissue Development	Regulation Of Growth Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Mesendoderm Development Regulation Of Transforming Growth Factor Beta2 Production Regulation Of MiRNA Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Cardiocyte Differentiation Cardiac Conduction System Development Regulation Of Epithelial Cell Proliferation Regulation Of Cell Growth Regulation Of Cellular Component Organization Epithelial Cell Proliferation Outflow Tract Septum Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Developmental Process Cellular Response To BMP Stimulus Pituitary Gland Development Negative Regulation Of Cell Growth Animal Organ Morphogenesis Endoderm Development Positive Regulation Of Epithelial Cell Proliferation Intracellular Signal Transduction Negative Regulation Of Cell-matrix Adhesion Ventricular Septum Morphogenesis Negative Regulation Of Growth Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Multicellular Organismal Process MAPK Cascade Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Neural Crest Cell Differentiation Embryonic Digit Morphogenesis Gland Development SMAD Binding Cellular Response To Growth Factor Stimulus Tube Morphogenesis Neural Plate Mediolateral Regionalization Paraxial Mesoderm Structural Organization Regulation Of Cardiac Muscle Cell Apoptotic Process Heart Morphogenesis Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Cell Development Cell Population Proliferation Tissue Development Fibrous Ring Of Heart Morphogenesis Mesoderm Development Positive Regulation Of Cardiac Ventricle Development Negative Regulation Of Cellular Component Organization Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric
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