PACS1 and MCAM

Number of citations of the paper that reports this interaction (PubMedID 38117590)
132

Data Source:
BioGRID (proximity labelling technology)

		PACS1	MCAM
Description		phosphofurin acidic cluster sorting protein 1	melanoma cell adhesion molecule
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol COPI-coated Vesicle	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Transmembrane Transporter Binding	Laminin Receptor Activity Protein Binding
	Biological Process	Lymphocyte Homeostasis Protein Localization To Golgi Apparatus Protein Localization To Plasma Membrane	Angiogenesis Glomerular Filtration Cell Adhesion Anatomical Structure Morphogenesis Positive Regulation Of Cell Migration Vascular Wound Healing
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 21926972 31043756 33263727 34002096) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Electroencephalogram traits ( 25387704) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Obesity (early onset extreme) ( 23563609) Serum uric acid levels ( 32514006) Waist circumference adjusted for body mass index ( 34021172)	Plateletcrit ( 32888494)
Interacting Genes		10 interacting genes: CLCN7 CSNK2A1 FURIN GGA3 IGF2R JUN PKD2 PPP2CA PPP2CB VAMP4	6 interacting genes: ADRB2 ATF7IP FYN LGALS3 PTK2B SHROOM1
Entrez ID		55690	4162
HPRD ID		06320	01120
Ensembl ID		ENSG00000175115	ENSG00000076706
Uniprot IDs		Q6VY07	P43121
PDB IDs			6LYN
Enriched GO Terms of Interacting Partners?		Response To Metal Ion Golgi To Plasma Membrane Transport Trans-Golgi Network Post-Golgi Vesicle-mediated Transport Trans-Golgi Network Transport Vesicle Liver Development Transforming Growth Factor Beta Receptor Signaling Pathway FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Response To Lead Ion Negative Regulation Of DNA Repair Vacuolar Transport Negative Regulation Of Double-strand Break Repair Vesicle-mediated Transport To The Plasma Membrane Response To Calcium Ion Host-mediated Activation Of Viral Process Phosphoprotein Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Transmembrane Transporter Binding Cellular Response To Fluid Shear Stress Metanephric Cortical Collecting Duct Development Response To Fluid Shear Stress Metanephric Cortex Development Metanephric Distal Tubule Development RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Golgi To Plasma Membrane Protein Transport Homocarnosine Synthase Activity Carnosine Synthase Activity Carnosine Biosynthetic Process Kinesin I Complex Tau Protein Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Chloride:proton Antiporter Activity Lysosome Positive Regulation Of Protein Catabolic Process Protein Targeting To Vacuole Rab GDP-dissociation Inhibitor Activity Leading Edge Cell Differentiation Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Peptidase Activity Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Polycystin Complex Metanephric Smooth Muscle Tissue Development	Glutamate Receptor Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Postsynaptic Density, Intracellular Component Bone Resorption Positive Regulation Of Excitatory Postsynaptic Potential Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Calcium Ion Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Cellular Response To Amyloid-beta Modulation Of Excitatory Postsynaptic Potential Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Calcium Ion Import Response To Amyloid-beta Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Neurotransmitter Receptor Regulator Activity Cellular Response To Glycine Response To Singlet Oxygen Regulation Of Bone Mineralization Cell Body Positive Regulation Of Cellular Component Organization Multicellular Organismal-level Homeostasis Beta2-adrenergic Receptor Activity Negative Regulation Of Multicellular Organismal Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of B Cell Chemotaxis Lymphocyte Activation Response To Glycine Positive Regulation Of Protein Localization To Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Regulation Of Nervous System Process Regulation Of Ossification Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Leukocyte Activation Protein Tyrosine Kinase Activity Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Negative Regulation Of NK T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Regulation Of Multicellular Organismal Development Regulation Of Cell Shape Transmembrane Transporter Binding Norepinephrine Binding Positive Regulation Of Neuron Projection Development
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