PACS1 and USP9Y

		PACS1	USP9Y
Description		phosphofurin acidic cluster sorting protein 1	ubiquitin specific peptidase 9 Y-linked
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol COPI-coated Vesicle	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Transmembrane Transporter Binding	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding Co-SMAD Binding
	Biological Process	Lymphocyte Homeostasis Protein Localization To Golgi Apparatus Protein Localization To Plasma Membrane	Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Cell Migration Protein Deubiquitination BMP Signaling Pathway Regulation Of Protein Stability
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression
Drugs
Diseases			Azoospermia, including: Azoospermia; Azoospermia due to perturbations of meiosis
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 21926972 31043756 33263727 34002096) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Electroencephalogram traits ( 25387704) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Obesity (early onset extreme) ( 23563609) Serum uric acid levels ( 32514006) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		10 interacting genes: CLCN7 CSNK2A1 FURIN GGA3 IGF2R JUN PKD2 PPP2CA PPP2CB VAMP4	3 interacting genes: MAPT RSPH1 UBC
Entrez ID		55690	8287
HPRD ID		06320	02449
Ensembl ID		ENSG00000175115	ENSG00000114374
Uniprot IDs		Q6VY07	O00507
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Metal Ion Golgi To Plasma Membrane Transport Trans-Golgi Network Post-Golgi Vesicle-mediated Transport Trans-Golgi Network Transport Vesicle Liver Development Transforming Growth Factor Beta Receptor Signaling Pathway FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Response To Lead Ion Negative Regulation Of DNA Repair Vacuolar Transport Negative Regulation Of Double-strand Break Repair Vesicle-mediated Transport To The Plasma Membrane Response To Calcium Ion Host-mediated Activation Of Viral Process Phosphoprotein Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Transmembrane Transporter Binding Cellular Response To Fluid Shear Stress Metanephric Cortical Collecting Duct Development Response To Fluid Shear Stress Metanephric Cortex Development Metanephric Distal Tubule Development RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Golgi To Plasma Membrane Protein Transport Homocarnosine Synthase Activity Carnosine Synthase Activity Carnosine Biosynthetic Process Kinesin I Complex Tau Protein Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Chloride:proton Antiporter Activity Lysosome Positive Regulation Of Protein Catabolic Process Protein Targeting To Vacuole Rab GDP-dissociation Inhibitor Activity Leading Edge Cell Differentiation Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Peptidase Activity Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Polycystin Complex Metanephric Smooth Muscle Tissue Development	Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Main Axon Regulation Of Tubulin Deacetylation Negative Regulation Of Mitochondrial Fission Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Tubulin Deacetylation Lipoprotein Particle Binding Neurofibrillary Tangle Assembly Inclusion Body Assembly Intracellular Distribution Of Mitochondria Minor Groove Of Adenine-thymine-rich DNA Binding Neurofibrillary Tangle Positive Regulation Of Protein Localization To Synapse Plus-end-directed Organelle Transport Along Microtubule Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Outer Dense Fiber Radial Spoke Head 1 Radial Spoke Head 3 Radial Spoke Head Regulation Of Cellular Response To Heat Regulation Of Protein Deacetylation Regulation Of Long-term Synaptic Depression Phosphatidylinositol Bisphosphate Binding Negative Regulation Of Membrane Potential Axolemma Axonal Transport Of Mitochondrion Dynactin Binding Negative Regulation Of Mitochondrial Membrane Potential Protein Tag Activity COPI-coated Vesicle Meiotic Spindle Radial Spoke Somatodendritic Compartment Nuclear Periphery Microtubule Cytoskeleton Organization Apolipoprotein Binding Astrocyte Activation Mitochondrion Distribution Response To Lead Ion Positive Regulation Of Superoxide Anion Generation Generation Of Neurons Regulation Of Superoxide Anion Generation Microtubule Polymerization Protein Phosphatase 2A Binding Regulation Of Mitochondrial Fission Regulation Of Protein Localization To Synapse Amyloid Fibril Formation Regulation Of Superoxide Metabolic Process
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