PCSK6 and FN3K

		PCSK6	FN3K
Description		proprotein convertase subtilisin/kexin type 6	fructosamine 3 kinase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Endomembrane System Membrane Extracellular Matrix	Mitochondrion Cytosol
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Nerve Growth Factor Binding	Nucleotide Binding ATP Binding Kinase Activity Transferase Activity Protein-ribulosamine 3-kinase Activity Protein-fructosamine 3-kinase Activity
	Biological Process	Proteolysis Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Production Secretion By Cell Plasma Lipoprotein Particle Remodeling	Fructosamine Metabolic Process Fructoselysine Metabolic Process Epithelial Cell Differentiation Protein Deglycation Post-translational Protein Modification
Pathways		Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Platelet-derived growth factor BB levels ( 27989323) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Severe coronary stenosis (young age of onset interaction) ( 33766035) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)	Glycated hemoglobin levels ( 20858683 24244560 24647736 29170429 31213470 34059833) Hemoglobin A1c levels ( 29403010 31217584) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		7 interacting genes: CACNA1A DYRK1A FLG PCSK5 PMCH RCN3 ZNF441	2 interacting genes: DSCR9 RBM11
Entrez ID		5046	64122
HPRD ID		01329	16336
Ensembl ID		ENSG00000140479	ENSG00000167363
Uniprot IDs		A2RQD9 H7BXT3 P29122 Q59H04	Q9H479
PDB IDs			8UE1 9CX8 9CXM 9CXN 9CXO 9CXV 9CXW
Enriched GO Terms of Interacting Partners?		Phosphoethanolamine Phosphatase Activity Response To Vitamin B6 Futile Creatine Cycle Phosphoamidase Activity Extracellular Membrane-bounded Organelle Response To Amyloid-beta Cellular Response To Amyloid-beta Peptidyl-tyrosine Phosphorylation Histone H3T45 Kinase Activity Type 1 Melanin-concentrating Hormone Receptor Binding Negative Regulation Of Synaptic Transmission, Dopaminergic Melanin-concentrating Hormone Activity Neurofilament Cytoskeleton Fast-twitch Skeletal Muscle Fiber Contraction Protein-fructosamine 3-kinase Activity Fructosamine Metabolic Process Protein Deglycation Protein-ribulosamine 3-kinase Activity Fructoselysine Metabolic Process	Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo Nerve Growth Factor Binding Anterior/posterior Axis Specification, Embryo
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