CD28 and WBP2NL

		CD28	WBP2NL
Description		CD28 molecule	WBP2 N-terminal like
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Protein Complex Involved In Cell Adhesion	Nucleus Perinuclear Theca Sperm Flagellum Sperm Head
	Molecular Function	Protein Binding Coreceptor Activity Protein Kinase Binding Identical Protein Binding	Transcription Coactivator Activity Protein Binding Chromatin DNA Binding WW Domain Binding
	Biological Process	Positive Regulation Of Cytokine Production Immune System Process Positive Regulation Of Inflammatory Response To Antigenic Stimulus Transcription By RNA Polymerase II Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Thymic T Cell Selection Regulatory T Cell Differentiation Positive Regulation Of Viral Genome Replication Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Egg Activation Male Pronucleus Assembly Positive Regulation Of DNA-templated Transcription Meiotic Cell Cycle Regulation Of Cytosolic Calcium Ion Concentration
Pathways		PIP3 activates AKT signaling Nef mediated downregulation of CD28 cell surface expression Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Graves' disease ( 21841780) Heschl's gyrus morphology ( 25130324) Inflammatory bowel disease ( 26192919) Lymphocyte count ( 32888494) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 28425483) Primary sclerosing cholangitis ( 27992413 23603763) Rheumatoid arthritis ( 24390342 30423114 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 26192919)	Autism spectrum disorder or schizophrenia ( 28540026) Breast size ( 22747683) Estimated glomerular filtration rate ( 31217584) Feeling tense ( 29500382) Intelligence ( 28530673) Isthmus-cingulate cortex volume ( 31530798) Platelet distribution width ( 27863252) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		25 interacting genes: AP1M1 BCS1L CAND1 CD247 CD4 CD80 CD86 CFLAR CTLA4 DUSP14 GRAP2 GRB2 IL12A ITK LCK LRRC23 NSF PIK3CG PIK3R1 PIK3R2 PLCG1 PTPRC SEC14L2 WBP2NL YAP1	2 interacting genes: CD28 CHADL
Entrez ID		940	164684
HPRD ID		01727	14512
Ensembl ID		ENSG00000178562	ENSG00000183066
Uniprot IDs		B4E0L1 P10747	Q6ICG8
PDB IDs		1YJD 3WA4 5AUL 5GJH 5GJI 6O8D 7PPN 7VU5 8S6Z 8W2V
Enriched GO Terms of Interacting Partners?		T Cell Activation Lymphocyte Activation Cell Activation Leukocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Mononuclear Cell Differentiation B Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Leukocyte Differentiation Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Differentiation Regulation Of T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of T Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Interleukin-2 Production Phosphatidylinositol 3-kinase Complex, Class IA Alpha-beta T Cell Activation Immune Response Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation T Cell Costimulation Immune Response-activating Signaling Pathway Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of Mononuclear Cell Proliferation Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Hemopoiesis Positive Regulation Of Metabolic Process Regulation Of Interleukin-2 Production Regulation Of Leukocyte Proliferation Intracellular Signal Transduction	Protein Complex Involved In Cell Adhesion Alpha-beta T Cell Proliferation Regulatory T Cell Differentiation Negative Thymic T Cell Selection Positive Regulation Of Inflammatory Response To Antigenic Stimulus Negative T Cell Selection Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Collagen Fibril Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Regulation Of Collagen Fibril Organization Negative Regulation Of Collagen Fibril Organization Positive Regulation Of Interleukin-10 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-4 Production T Cell Costimulation Regulation Of Interleukin-4 Production Thymic T Cell Selection Positive Regulation Of Isotype Switching Immunological Synapse Regulation Of Regulatory T Cell Differentiation T Cell Selection Positive Regulation Of Viral Genome Replication Positive Regulation Of Interleukin-2 Production Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Alpha-beta T Cell Proliferation Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Chondrocyte Differentiation Negative Regulation Of Cartilage Development Positive Regulation Of Immunoglobulin Production Regulation Of Interleukin-2 Production Coreceptor Activity Regulation Of Interleukin-10 Production Regulation Of Multicellular Organismal Development CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Viral Process Regulation Of Chondrocyte Differentiation Collagen Binding Regulation Of Extracellular Matrix Organization Regulation Of Cell Differentiation Positive Regulation Of DNA Recombination Regulation Of Viral Genome Replication T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Activation Regulation Of Cartilage Development
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