CD28 and CD247

Number of citations of the paper that reports this interaction (PubMedID 8760790)
89

Data Source:
HPRD (in vivo)

		CD28	CD247
Description		CD28 molecule	CD247 molecule
Image
GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Protein Complex Involved In Cell Adhesion	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Fc-gamma Receptor III Complex T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Plasma Membrane Protein Complex
	Molecular Function	Protein Binding Coreceptor Activity Protein Kinase Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Tyrosine Kinase Binding
	Biological Process	Positive Regulation Of Cytokine Production Immune System Process Positive Regulation Of Inflammatory Response To Antigenic Stimulus Transcription By RNA Polymerase II Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Thymic T Cell Selection Regulatory T Cell Differentiation Positive Regulation Of Viral Genome Replication Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein Complex Oligomerization Protein-containing Complex Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways		PIP3 activates AKT signaling Nef mediated downregulation of CD28 cell surface expression Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Muromonab Teclistamab Odronextamab
Diseases
GWAS		Alopecia areata ( 25608926) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Graves' disease ( 21841780) Heschl's gyrus morphology ( 25130324) Inflammatory bowel disease ( 26192919) Lymphocyte count ( 32888494) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 28425483) Primary sclerosing cholangitis ( 27992413 23603763) Rheumatoid arthritis ( 24390342 30423114 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 26192919)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 34103634 31361310 31619474 31959851 32296059 30929738 27182965) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Systemic sclerosis ( 31672989 29293537 21779181 21750679 20383147)
Interacting Genes		25 interacting genes: AP1M1 BCS1L CAND1 CD247 CD4 CD80 CD86 CFLAR CTLA4 DUSP14 GRAP2 GRB2 IL12A ITK LCK LRRC23 NSF PIK3CG PIK3R1 PIK3R2 PLCG1 PTPRC SEC14L2 WBP2NL YAP1	38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		940	919
HPRD ID		01727	01729
Ensembl ID		ENSG00000178562	ENSG00000198821
Uniprot IDs		B4E0L1 P10747	A0A8V8TPP4 A0A8V8TQM0 P20963 Q6KAV0
PDB IDs		1YJD 3WA4 5AUL 5GJH 5GJI 6O8D 7PPN 7VU5 8S6Z 8W2V	1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8J8I 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
Enriched GO Terms of Interacting Partners?		T Cell Activation Lymphocyte Activation Cell Activation Leukocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Mononuclear Cell Differentiation B Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Leukocyte Differentiation Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Differentiation Regulation Of T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of T Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Interleukin-2 Production Phosphatidylinositol 3-kinase Complex, Class IA Alpha-beta T Cell Activation Immune Response Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation T Cell Costimulation Immune Response-activating Signaling Pathway Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of Mononuclear Cell Proliferation Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Hemopoiesis Positive Regulation Of Metabolic Process Regulation Of Interleukin-2 Production Regulation Of Leukocyte Proliferation Intracellular Signal Transduction	Lymphocyte Activation Immune System Process Leukocyte Activation Cell Activation Signal Transduction Positive Regulation Of Immune System Process Natural Killer Cell Activation T Cell Activation Regulation Of Lymphocyte Activation Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Immune Response-activating Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Plasma Membrane T Cell Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Lymphocyte Mediated Immunity Positive Regulation Of Cell-cell Adhesion Leukocyte Mediated Cytotoxicity T Cell Costimulation Phosphotyrosine Residue Binding Regulation Of T Cell Receptor Signaling Pathway Leukocyte Mediated Immunity Immune Effector Process Positive Regulation Of Cell Adhesion Adaptive Immune Response Regulation Of Mononuclear Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Leukocyte Proliferation Regulation Of Lymphocyte Mediated Immunity T Cell Receptor Complex Natural Killer Cell Mediated Immunity Alpha-beta T Cell Receptor Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?