CD28 and ITK

Number of citations of the paper that reports this interaction (PubMedID 8992971)
0

Data Source:
HPRD (in vitro, in vivo)

		CD28	ITK
Description		CD28 molecule	IL2 inducible T cell kinase
Image
GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Protein Complex Involved In Cell Adhesion	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction
	Molecular Function	Protein Binding Coreceptor Activity Protein Kinase Binding Identical Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Cytokine Production Immune System Process Positive Regulation Of Inflammatory Response To Antigenic Stimulus Transcription By RNA Polymerase II Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Thymic T Cell Selection Regulatory T Cell Differentiation Positive Regulation Of Viral Genome Replication Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Positive Regulation Of Cytokine Production NK T Cell Differentiation Adaptive Immune Response Immune System Process Cellular Defense Response Signal Transduction Intracellular Signal Transduction T Cell Activation Gamma-delta T Cell Activation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		PIP3 activates AKT signaling Nef mediated downregulation of CD28 cell surface expression Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Generation of second messenger molecules FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs			Staurosporine Pazopanib Fostamatinib Zanubrutinib
Diseases
GWAS		Alopecia areata ( 25608926) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Graves' disease ( 21841780) Heschl's gyrus morphology ( 25130324) Inflammatory bowel disease ( 26192919) Lymphocyte count ( 32888494) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 28425483) Primary sclerosing cholangitis ( 27992413 23603763) Rheumatoid arthritis ( 24390342 30423114 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 26192919)	Asthma ( 31959851 34103634) Daytime sleep phenotypes ( 27126917) Eosinophil count ( 32888494) Heel bone mineral density ( 30598549) Personality traits in bipolar disorder ( 21368711) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)
Interacting Genes		25 interacting genes: AP1M1 BCS1L CAND1 CD247 CD4 CD80 CD86 CFLAR CTLA4 DUSP14 GRAP2 GRB2 IL12A ITK LCK LRRC23 NSF PIK3CG PIK3R1 PIK3R2 PLCG1 PTPRC SEC14L2 WBP2NL YAP1	35 interacting genes: BLNK BMX BTK CBL CD28 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FGFR1 FYN GAB1 GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 MET PDGFRB PLCG1 PLCG2 PPIA SH2D2A SMAD4 SMURF1 SOCS1 SPRR2A SRC TGFBR1 WAS
Entrez ID		940	3702
HPRD ID		01727	01746
Ensembl ID		ENSG00000178562	ENSG00000113263
Uniprot IDs		B4E0L1 P10747	Q08881
PDB IDs		1YJD 3WA4 5AUL 5GJH 5GJI 6O8D 7PPN 7VU5 8S6Z 8W2V	1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO 4L7S 4M0Y 4M0Z 4M12 4M13 4M14 4M15 4MF0 4MF1 4PP9 4PPA 4PPB 4PPC 4PQN 4QD6 4RFM
Enriched GO Terms of Interacting Partners?		T Cell Activation Lymphocyte Activation Cell Activation Leukocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Mononuclear Cell Differentiation B Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Leukocyte Differentiation Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Differentiation Regulation Of T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of T Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Interleukin-2 Production Phosphatidylinositol 3-kinase Complex, Class IA Alpha-beta T Cell Activation Immune Response Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation T Cell Costimulation Immune Response-activating Signaling Pathway Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of Mononuclear Cell Proliferation Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Hemopoiesis Positive Regulation Of Metabolic Process Regulation Of Interleukin-2 Production Regulation Of Leukocyte Proliferation Intracellular Signal Transduction	Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Activation Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Signal Transduction Phospholipase Binding ERBB Signaling Pathway Regulation Of Apoptotic Process Immune System Process Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Protein Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Immune Response Intracellular Signaling Cassette Leukocyte Activation Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Kinase Activity Regulation Of Immune Response Regulation Of MAPK Cascade Membrane Raft Positive Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of Programmed Cell Death ERBB2 Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Binding
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