SDHC and DEDD

		SDHC	DEDD
Description		succinate dehydrogenase complex subunit C	death effector domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex II (succinate Dehydrogenase)	Nucleus Nucleolus Cytoplasm
	Molecular Function	Protein Binding Electron Transfer Activity Heme Binding Metal Ion Binding	DNA Binding Protein Binding
	Biological Process	Tricarboxylic Acid Cycle Mitochondrial Electron Transport, Succinate To Ubiquinone Aerobic Respiration Proton Motive Force-driven Mitochondrial ATP Synthesis	Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Decidualization Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1
Diseases
GWAS		Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		6 interacting genes: ARHGDIA DEDD MDM2 RBFOX2 RGS4 XRCC6	24 interacting genes: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 IRF9 KRT18 KRT8 MPZ NR1I3 PRRC2C SDHC SHMT1 SLC19A2 SMAD3 UAP1 VPS26A
Entrez ID		6391	9191
HPRD ID		03878	06022
Ensembl ID		ENSG00000143252	ENSG00000158796
Uniprot IDs		A0A0S2Z4B7 A0A0S2Z4C9 A0AAQ5BHE7 Q99643	B1AQP5 O75618
PDB IDs		8GS8
Enriched GO Terms of Interacting Partners?		Cellular Response To Gamma Radiation Rho GDP-dissociation Inhibitor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Response To Gamma Radiation DNA End Binding Negative Regulation Of DNA-templated Transcription Response To Ionizing Radiation Ku70:Ku80 Complex Cellular Response To Ionizing Radiation Negative Regulation Of RNA Biosynthetic Process Response To Alkaloid Response To Vitamin B1 Response To Water-immersion Restraint Stress Response To Formaldehyde Cellular Response To Vitamin B1 Response To Cocaine Cellular Response To Actinomycin D Regulation Of Heart Rate Negative Regulation Of Glycine Import Across Plasma Membrane Negative Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation NEDD8 Ligase Activity Response To Actinomycin D Regulation Of Muscle Cell Differentiation Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Radiation Cellular Hyperosmotic Salinity Response Protein-containing Complex DNA-dependent Protein Kinase Complex Cellular Response To UV-C Dorsal Root Ganglion Development Hyperosmotic Salinity Response Receptor Serine/threonine Kinase Binding Regulation Of Heart Contraction DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity GTPase Activator Activity Nucleus Nucleolus Cellular Response To X-ray Negative Regulation Of Macromolecule Biosynthetic Process Nuclear Telomere Cap Complex Cellular Response To Salt Stress Double-stranded Telomeric DNA Binding Nonhomologous End Joining Complex Regulation Of Blood Circulation Atrial Septum Development	Ripoptosome CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Apoptotic Signaling Pathway Death Effector Domain Binding Positive Regulation Of Neuron Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cysteine-type Endopeptidase Activity Positive Regulation Of Execution Phase Of Apoptosis Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Neuron Apoptotic Process Response To Anesthetic Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Cysteine-type Peptidase Activity Response To External Biotic Stimulus Epithelial Cell Apoptotic Process Positive Regulation Of Pyroptotic Inflammatory Response TRAIL-activated Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Response To Cobalt Ion Positive Regulation Of Interleukin-1 Beta Production Regulation Of Programmed Cell Death TRNA Transcription By RNA Polymerase III TRNA Transcription RNA Polymerase III General Transcription Initiation Factor Activity Scaffold Protein Binding Positive Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Cell Body Positive Regulation Of Macrophage Differentiation Hepatocyte Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction DNA Binding Transition Metal Ion Binding Platelet Alpha Granule Negative Regulation Of Necroptotic Process Regulation Of Interleukin-1 Beta Production Myeloid Cell Differentiation
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