DEDD and VPS26A

		DEDD	VPS26A
Description		death effector domain containing	VPS26 retromer complex component A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Cytoplasm Lysosome Endosome Early Endosome Cytosol Endosome Membrane Membrane Retromer Complex Retromer, Cargo-selective Complex Vesicle Tubular Endosome
	Molecular Function	DNA Binding Protein Binding	Protein Binding
	Biological Process	Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Decidualization Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I	Intracellular Protein Transport Protein Transport Regulation Of Macroautophagy Endocytic Recycling Retrograde Transport, Endosome To Golgi
Pathways			WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS			Body size at age 10 ( 32376654) Glycemic traits (pregnancy) ( 23903356) Immune reponse to smallpox (secreted IL-1beta) ( 22610502) Type 2 diabetes ( 21874001 30718926)
Interacting Genes		24 interacting genes: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 IRF9 KRT18 KRT8 MPZ NR1I3 PRRC2C SDHC SHMT1 SLC19A2 SMAD3 UAP1 VPS26A	4 interacting genes: DEDD MORF4L1 VPS26C ZSCAN12
Entrez ID		9191	9559
HPRD ID		06022	08385
Ensembl ID		ENSG00000158796	ENSG00000122958
Uniprot IDs		B1AQP5 O75618	B4DLT1 O75436
PDB IDs			2FAU 5F0J 5F0L 5F0M 5F0P 7BLO
Enriched GO Terms of Interacting Partners?		Ripoptosome CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Apoptotic Signaling Pathway Death Effector Domain Binding Positive Regulation Of Neuron Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cysteine-type Endopeptidase Activity Positive Regulation Of Execution Phase Of Apoptosis Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Neuron Apoptotic Process Response To Anesthetic Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Cysteine-type Peptidase Activity Response To External Biotic Stimulus Epithelial Cell Apoptotic Process Positive Regulation Of Pyroptotic Inflammatory Response TRAIL-activated Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Response To Cobalt Ion Positive Regulation Of Interleukin-1 Beta Production Regulation Of Programmed Cell Death TRNA Transcription By RNA Polymerase III TRNA Transcription RNA Polymerase III General Transcription Initiation Factor Activity Scaffold Protein Binding Positive Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Cell Body Positive Regulation Of Macrophage Differentiation Hepatocyte Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction DNA Binding Transition Metal Ion Binding Platelet Alpha Granule Negative Regulation Of Necroptotic Process Regulation Of Interleukin-1 Beta Production Myeloid Cell Differentiation
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